Recent developments of useful MALDI matrices for the mass spectrometric characterization of lipids

J Leopold, Y Popkova, KM Engel, J Schiller - Biomolecules, 2018 - mdpi.com
Matrix-assisted laser desorption/ionization (MALDI) is one of the most successful “soft”
ionization methods in the field of mass spectrometry and enables the analysis of a broad …

Recent developments of novel matrices and on-tissue chemical derivatization reagents for MALDI-MSI

Q Zhou, A Fülöp, C Hopf - Analytical and bioanalytical chemistry, 2021 - Springer
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a fast-
growing technique for visualization of the spatial distribution of the small molecular and …

[HTML][HTML] MALDI HiPLEX-IHC: multiomic and multimodal imaging of targeted intact proteins in tissues

MJ Lim, G Yagnik, C Henkel, SF Frost, T Bien… - Frontiers in …, 2023 - frontiersin.org
Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is one
of the most widely used methods for imaging the spatial distribution of unlabeled small …

Empowering clinical diagnostics with mass spectrometry

S Banerjee - ACS omega, 2020 - ACS Publications
The unmet need for highly accurate methods of disease diagnosis poses new challenges for
developments in laboratory medicine. Advances in mass spectrometry (MS)-based disease …

Mass spectrometry-based proteomics as an emerging tool in clinical laboratories

AG Birhanu - Clinical Proteomics, 2023 - Springer
Mass spectrometry (MS)-based proteomics have been increasingly implemented in various
disciplines of laboratory medicine to identify and quantify biomolecules in a variety of …

Aggregated molecular phenotype scores: enhancing assessment and visualization of mass spectrometry imaging data for tissue-based diagnostics

JR Chappel, ME King, J Fleming, LS Eberlin… - Analytical …, 2023 - ACS Publications
Mass spectrometry imaging (MSI) has gained increasing popularity for tissue-based
diagnostics due to its ability to identify and visualize molecular characteristics unique to …

Mass spectrometry imaging to detect lipid biomarkers and disease signatures in cancer

M Holzlechner, E Eugenin, B Prideaux - Cancer reports, 2019 - Wiley Online Library
Background Current methods to identify, classify, and predict tumor behavior mostly rely on
histology, immunohistochemistry, and molecular determinants. However, better predictive …

Unravelling prostate cancer heterogeneity using spatial approaches to lipidomics and transcriptomics

SM Mutuku, X Spotbeen, PJ Trim, MF Snel, LM Butler… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer is a heterogenous disease in terms of disease
aggressiveness and therapy response, leading to dilemmas in treatment decisions. This …

Mass spectrometry technologies to advance care for cancer patients in clinical and intraoperative use

J Zhang, M Sans, KY Garza… - Mass spectrometry …, 2021 - Wiley Online Library
Developments in mass spectrometry technologies have driven a widespread interest and
expanded their use in cancer‐related research and clinical applications. In this review, we …

Cross-normalization of MALDI mass spectrometry imaging data improves site-to-site reproducibility

T Boskamp, R Casadonte, L Hauberg-Lotte… - Analytical …, 2021 - ACS Publications
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is an
established tool for the investigation of formalin-fixed paraffin-embedded (FFPE) tissue …