The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

The endosomal system is expansive and complex, characterized by swift morphological
transitions, dynamic remodeling of membrane constituents, and intracellular positioning …

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
become a global pandemic and has claimed over 2 million lives worldwide. Although the …

SARS-CoV-2 infection have caused global pandemic and claimed over 5,000,000 tolls–.
Although the genetic sequences of their etiologic viruses are of high homology, the clinical …

Interest in MHC-E–restricted CD8+ T cell responses has been aroused by the discovery of
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …

HIV-1 has evolved mechanisms to evade host cell immune responses and persist for lifelong
infection. Latent cellular reservoirs are responsible for this persistence of HIV-1 despite the …

Autophagy is a cytoplasmic degradative pathway that can participate in biosynthetic
processes, as in the yeast Cvt pathway, but is more commonly known for its functions in …

One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes
them from other retroviruses is the array of" accessory" proteins they encode. Here, we …

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the
host with an important surveillance mechanism to protect against invading pathogens …

The trans-Golgi network (TGN) is an important cargo sorting station within the cell where
newly synthesized proteins are packaged into distinct transport carriers that are targeted to …