Inhibiting degradation of 2-arachidonoylglycerol as a therapeutic strategy for neurodegenerative diseases
C Chen - Pharmacology & therapeutics, 2023 - Elsevier
Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …
Positron emission tomography imaging of the endocannabinoid system: opportunities and challenges in radiotracer development
The endocannabinoid system (ECS) is involved in a wide range of biological functions and
comprises cannabinoid receptors and enzymes responsible for endocannabinoid synthesis …
comprises cannabinoid receptors and enzymes responsible for endocannabinoid synthesis …
Cerebellar dopamine D2 receptors regulate social behaviors
The cerebellum, a primary brain structure involved in the control of sensorimotor tasks, also
contributes to higher cognitive functions including reward, emotion and social interaction …
contributes to higher cognitive functions including reward, emotion and social interaction …
Targeting monoacylglycerol lipase in pursuit of therapies for neurological and neurodegenerative diseases
Neurological and neurodegenerative diseases are debilitating conditions, and frequently
lack an effective treatment. Monoacylglycerol lipase (MAGL) is a key enzyme involved in the …
lack an effective treatment. Monoacylglycerol lipase (MAGL) is a key enzyme involved in the …
Endocannabinoids regulate enteric neuron–glia networks and visceral hypersensitivity following inflammation through a glial‐dependent mechanism
Acute gastrointestinal (GI) inflammation induces neuroplasticity that produces long‐lasting
changes in gut motor function and pain. The endocannabinoid system is an attractive target …
changes in gut motor function and pain. The endocannabinoid system is an attractive target …
Exposure to Δ9-tetrahydrocannabinol leads to a rise in caspase-3, morphological changes in microglial, and astrocyte reactivity in the cerebellum of rats
M Mohammadpanah, S Farrokhi, M Sani… - Toxicology …, 2023 - academic.oup.com
The present study aimed to elucidate the effect of 10 mg/kg Δ9-tetrahydrocannabinol (THC)
on cerebellar neuronal and glial morphology, apoptosis and inflammatory gene expression …
on cerebellar neuronal and glial morphology, apoptosis and inflammatory gene expression …
Insights into the advances in therapeutic drugs for neuroinflammation-related diseases
B Luo - International Journal of Neuroscience, 2024 - Taylor & Francis
Studies have shown that neurodegenerative diseases such as AD and PD are related to
neuroinflammation. Neuroinflammation is a common inflammatory condition that can lead to …
neuroinflammation. Neuroinflammation is a common inflammatory condition that can lead to …
Augmentation of Endogenous 2-Arachidonoylglycerol Mitigates Autistic Behaviors of BTBR Mice
M Zou, Y Zhang, C Du, B Yang, P Guo, H Liang… - Molecular …, 2024 - Springer
The lipid-based endocannabinoid (eCB) system regulates a host of developmental,
physiological, and pathological processes in the mammalian brain, and recent studies have …
physiological, and pathological processes in the mammalian brain, and recent studies have …
Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice
Nicotine, the primary psychoactive component in tobacco, plays a major role in the initiation
and maintenance of tobacco dependence and addiction, a leading cause of preventable …
and maintenance of tobacco dependence and addiction, a leading cause of preventable …
CB2 receptors and Neuron–Glia interactions modulate neurotoxicity generated by MAGL inhibition
E Rojo-Bustamante, I Íñigo-Marco, MA Abellanas… - Biomolecules, 2020 - mdpi.com
Monoacylglycerol lipase inhibition (MAGL) has emerged as an interesting therapeutic target
for neurodegenerative disease treatment due to its ability to modulate the endocannabinoid …
for neurodegenerative disease treatment due to its ability to modulate the endocannabinoid …