The role of European healthcare databases for post-marketing drug effectiveness, safety and value evaluation: where does Italy stand?
Enormous progress has been made globally in the use of evidence derived from patients'
clinical information as they access their routine medical care. The value of real-world data …
clinical information as they access their routine medical care. The value of real-world data …
Generating evidence from computerized healthcare utilization databases
Corrao and Mancia Real-World Data and Clinical Research 491 and MR databases, in
comparison with conventional sources of healthcare information, is provided in Table 1. 17 …
comparison with conventional sources of healthcare information, is provided in Table 1. 17 …
Cardiovascular outcomes and mortality associated with discontinuing statins in older patients receiving polypharmacy
Importance Polypharmacy is a major health concern among older adults. While
deprescribing may reduce inappropriate medicine use, its effect on clinical end points …
deprescribing may reduce inappropriate medicine use, its effect on clinical end points …
Adherence to antidiabetic drug therapy and reduction of fatal events in elderly frail patients
Background To evaluate the protective effect of oral antidiabetic drugs in a large cohort of
elderly patients with type 2 diabetes differing for age, clinical status, and life expectancy …
elderly patients with type 2 diabetes differing for age, clinical status, and life expectancy …
[HTML][HTML] Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride
T Kiguradze, WH Temps, PR Yarnold, J Cashy… - PeerJ, 2017 - peerj.com
Objective Our chief objective was to assess whether longer duration of 5α-RI exposure
increases risk of PED, independent of age and other known risk factors. Men with shorter 5α …
increases risk of PED, independent of age and other known risk factors. Men with shorter 5α …
Adjuvanted versus non-adjuvanted standard-dose influenza vaccines in preventing all-cause hospitalizations in the elderly: a cohort study with nested case-control …
Background The higher effectiveness of adjuvanted trivalent influenza vaccine (aTIV) versus
non-adjuvanted (na) formulations in preventing all-cause hospitalization has been …
non-adjuvanted (na) formulations in preventing all-cause hospitalization has been …
Risk of Dementia during antihypertensive drug therapy in the elderly
Background Evidence exists that lowering high blood pressure reduces the risk of dementia.
However, the generalizability of this evidence to old patients from the general population …
However, the generalizability of this evidence to old patients from the general population …
Use of non-steroidal anti-inflammatory drugs correlates with the risk of venous thromboembolism in knee osteoarthritis patients: a UK population-based case-control …
Objective. We aimed to examine whether the current users of specific NSAIDs have an
increased risk of venous thromboembolism (VTE) among knee OA patients. Methods. We …
increased risk of venous thromboembolism (VTE) among knee OA patients. Methods. We …
Statin treatment reduces the risk of death among elderly frail patients: evidence from a large population-based cohort
Aims To assess the protective effect of statins in a large and unselected cohort of frail elderly
subjects. Methods and results The 460 460 Lombardy residents (Italy), aged≥ 65 years …
subjects. Methods and results The 460 460 Lombardy residents (Italy), aged≥ 65 years …
Use of statin for the primary prevention of cardiovascular outcomes in elderly patients: A propensity-matched cohort study
Y Cho, Y Jeong, DH Seo, SH Ahn, S Hong, YJ Suh… - Atherosclerosis, 2021 - Elsevier
Background and aims Herein, we investigate whether statin treatment as primary prevention
reduces cardiovascular outcomes in elderly Asian patients. Methods Data were obtained …
reduces cardiovascular outcomes in elderly Asian patients. Methods Data were obtained …