Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Gut microbiota and immune system interactions

JY Yoo, M Groer, SVO Dutra, A Sarkar, DI McSkimming - Microorganisms, 2020 - mdpi.com
Dynamic interactions between gut microbiota and a host's innate and adaptive immune
systems are essential in maintaining intestinal homeostasis and inhibiting inflammation. Gut …

Gut dysbiosis: Ecological causes and causative effects on human disease

SE Winter, AJ Bäumler - Proceedings of the National Academy of …, 2023 - pnas.org
The gut microbiota plays a role in many human diseases, but high-throughput sequence
analysis does not provide a straightforward path for defining healthy microbial communities …

Salmonella Typhimurium and inflammation: a pathogen-centric affair

JE Galán - Nature Reviews Microbiology, 2021 - nature.com
Microbial infections are controlled by host inflammatory responses that are initiated by
innate immune receptors after recognition of conserved microbial products. As inflammation …

Host–microbiota interactions in inflammatory bowel disease

R Caruso, BC Lo, G Núñez - Nature Reviews Immunology, 2020 - nature.com
The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

The role of Enterobacteriaceae in gut microbiota dysbiosis in inflammatory bowel diseases

V Baldelli, F Scaldaferri, L Putignani, F Del Chierico - Microorganisms, 2021 - mdpi.com
Inflammatory bowel diseases (IBDs) are a group of chronic gastrointestinal inflammatory
diseases with unknown etiology. There is a combination of well documented factors in their …

[HTML][HTML] Mechanism of the gut microbiota colonization resistance and enteric pathogen infection

I Khan, Y Bai, L Zha, N Ullah, H Ullah… - Frontiers in Cellular …, 2021 - frontiersin.org
The mammalian gut microbial community, known as the gut microbiota, comprises trillions of
bacteria, which co-evolved with the host and has an important role in a variety of host …

The microbiome, cancer, and cancer therapy

BA Helmink, MAW Khan, A Hermann… - Nature medicine, 2019 - nature.com
With the advent of next-generation sequencing, we have an unprecedented ability to study
tumor and host genomes as well as those of the vast array of microorganisms that exist …

Commensal consortia decolonize Enterobacteriaceae via ecological control

M Furuichi, T Kawaguchi, MM Pust, K Yasuma-Mitobe… - Nature, 2024 - nature.com
Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine
can result from long-term antibiotic use or inflammatory conditions, and may perpetuate …

The impact of oxidative stress in human pathology: Focus on gastrointestinal disorders

R Vona, L Pallotta, M Cappelletti, C Severi… - Antioxidants, 2021 - mdpi.com
Accumulating evidence shows that oxidative stress plays an essential role in the
pathogenesis and progression of many diseases. The imbalance between the production of …