Electrical and mechanical stimulation of cardiac cells and tissue constructs
The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …
decades, highlighted by the development of human cell derived constructs that have shown …
Signaling pathways in cardiac myocyte apoptosis
Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …
RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria
Mitophagy, a mitochondria-specific form of autophagy, removes dysfunctional mitochondria
and is hence an essential process contributing to mitochondrial quality control. PTEN …
and is hence an essential process contributing to mitochondrial quality control. PTEN …
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil
Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
Focal adhesion kinase and its role in skeletal muscle
Skeletal muscle has a remarkable ability to respond to different physical stresses. Loading
muscle through exercise, either anaerobic or aerobic, can lead to increases in muscle size …
muscle through exercise, either anaerobic or aerobic, can lead to increases in muscle size …
Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload
Cardiovascular disease (CVD) remains the leading cause of death globally, and heart
failure is a major component of CVD-related morbidity and mortality. The development of …
failure is a major component of CVD-related morbidity and mortality. The development of …
Rho kinase as a therapeutic target in cardiovascular disease
Rho kinase (ROCK) belongs to the AGC (PKA/PKG/PKC) family of serine/threonine kinases
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …
Untangling the role of RhoA in the heart: protective effect and mechanism
S Miyamoto - Cell Death & Disease, 2024 - nature.com
RhoA (ras homolog family member A) is a small G-protein that transduces intracellular
signaling to regulate a broad range of cellular functions such as cell growth, proliferation …
signaling to regulate a broad range of cellular functions such as cell growth, proliferation …
mTOR and the health benefits of exercise
K Watson, K Baar - Seminars in cell & developmental biology, 2014 - Elsevier
Exercise is the greatest physiological stress that our bodies experience. For example, during
maximal endurance exercise in elite athlete's cardiac output can increase up to 8-fold and …
maximal endurance exercise in elite athlete's cardiac output can increase up to 8-fold and …
RhoA: a dubious molecule in cardiac pathophysiology
The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase
superfamily originally studied in cancer cells where it was found to stimulate cell cycle …
superfamily originally studied in cancer cells where it was found to stimulate cell cycle …