Ribonucleoprotein (RNP) granules are diverse membrane-less organelles that form through
multivalent RNA-RNA, RNA-protein, and protein-protein interactions between RNPs. RNP …

Stress granules (SGs) are dynamic membraneless organelles that form in response to
cellular stress. SGs are predominantly composed of RNA and RNA-binding proteins that …

The ability to map trafficking for thousands of endogenous proteins at once in living cells
would reveal biology currently invisible to both microscopy and mass spectrometry. Here, we …

Stress granule formation is triggered by the release of mRNAs from polysomes and is
promoted by the action of the RNA-binding proteins G3BP1/2. Stress granules have been …

Autophagy and ribonucleoprotein granules, such as P-bodies (PBs) and stress granules,
represent vital stress responses to maintain cellular homeostasis. SQSTM1/p62 phase …

A hexanucleotide (GGGGCC) n repeat expansion in C9orf72 causes amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD), eliciting toxic effects through generation …

Purinosomes serve as metabolons to enhance de novo purine synthesis (DNPS) efficiency
through compartmentalizing DNPS enzymes during stressed conditions. However, the …

The most common inherited cause of two genetically and clinico-pathologically overlap**
neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal …

Stress granules (SGs) are conserved reversible cytoplasmic condensates enriched with
aggregation-prone proteins assembled in response to various stresses. How plants regulate …

Although the composition and assembly of stress granules (SGs) are well understood, the
molecular mechanisms underlying SG disassembly remain unclear. Here, we identify that …