The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway
mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence …

Hypoxia‐inducible factors (HIFs) are core regulators of the hypoxia response. HIF signaling
is activated in the local physiological and pathological hypoxic environment, acting on …

Acute kidney injury (AKI), a major health issue concerning~ 50% of patients treated in
intensive care units, generally leads to severe renal damage associated with high mortality …

Rationale: Acute kidney injury (AKI) is a common critical illness in the clinic and currently
lacks effective treatment options. Ischemia reperfusion injury (IRI) is a major pathogenic …

Rationale: Ischemia-reperfusion injury (I/R) is a common cause of acute kidney injury (AKI).
Post-ischemic recovery of renal blood supply plays an important role in attenuating injury …

Oxygen homeostasis disturbances play a critical role in the pathogenesis of acute kidney
injury (AKI). The transcription factor hypoxia-inducible factor-1 (HIF-1) is a master regulator …

Acute kidney injury (AKI) is associated with a high mortality rate. Pathologically, renal
ischemia/reperfusion injury (RIRI) is one of the primary causes of AKI, and hypoxia-inducible …

Objectives Currently, cardiovascular risk associated with COVID-19 has been brought to
people's attention, but the mechanism is not clear. The aim of this study is to elucidate the …

Abstract Coronavirus disease 2019 (COVID-19) is a pandemic of unprecedented severity
affecting millions of people around the world and causing several hundred thousands of …

Background Hypertension has a high morbidity in the general population, especially in the
developed countries, and is regarded as the second leading cause of chronic kidney …