Pertussis, which is caused by Bordetella pertussis, has plagued humans for at least 800
years, is highly infectious and can be fatal in the unvaccinated, especially very young …

Pertussis or whoo** cough has persisted and resurged in the face of vaccination and has
become one of the most prevalent vaccine-preventable diseases in Western countries. The …

BACKGROUND AND OBJECTIVES: Pertussis incidence is increasing, possibly due to the
introduction of acellular vaccines, which may have decreased the durability of immune …

METHODS: We modeled pertussis risk in relation to Tdap vaccination status among
adolescents beginning on their 10th birthday. We estimated the hazard ratio (HR) for each …

Bordetella pertussis is a pathogen-causing whoo** cough (pertussis) in humans.
Although vaccination against the disease is effective, the bacterium is still circulating among …

Varicella-zoster virus (VZV) T-cell-mediated immunity (VZV-CMI) in older persons prevents
latent VZV in sensory neurons from reactivating to cause herpes zoster. VZV-CMI declines …

Pathogen adaptation has been proposed to contribute to the resurgence of pertussis. A
striking recent example is the emergence of isolates deficient in the vaccine component …

The UK is currently in the midst of a large outbreak of pertussis, with the highest morbidity
and mortality occurring in young unimmunised infants. This review considers the potential …

The United States switched from whole cell to acellular pertussis vaccines in the 1990s
following global concerns with the safety of the whole cell vaccines. Despite high levels of …

Objective Countries routinely offering acellular pertussis vaccine, where long-term protection
is not sustained, have the challenge of selecting an optimal schedule to minimise disease …