Current aspects of the endocannabinoid system and targeted THC and CBD phytocannabinoids as potential therapeutics for Parkinson's and Alzheimer's diseases: a …
Neurodegeneration leading to Parkinson's disease (PD) and Alzheimer's disease (AD) has
become a major health burden globally. Current treatments mainly target controlling …
become a major health burden globally. Current treatments mainly target controlling …
New insights in cannabinoid receptor structure and signaling
L Ye, Z Cao, W Wang, N Zhou - Current molecular …, 2019 - ingentaconnect.com
Background: Cannabinoid has long been used for medicinal purposes. Cannabinoid
signaling has been considered the therapeutic target for treating pain, addiction, obesity …
signaling has been considered the therapeutic target for treating pain, addiction, obesity …
Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown
PH Reggio - Current medicinal chemistry, 2010 - ingentaconnect.com
The cannabinoid CB1 and CB2 receptors are Class AG protein-coupled receptors (GPCRs).
While many Class A GPCRs have endogenous ligands that are hydrophilic cations (eg, the …
While many Class A GPCRs have endogenous ligands that are hydrophilic cations (eg, the …
Progress in structure based drug design for G protein-coupled receptors
In 1998, Bikker, Trumpp-Kallmeyer, and Humblet published a Perspective in this journal
entitled “G-Protein Coupled Receptors: Models, Mutagenesis and Drug Design” and …
entitled “G-Protein Coupled Receptors: Models, Mutagenesis and Drug Design” and …
Modeling, molecular dynamics simulation, and mutation validation for structure of cannabinoid receptor 2 based on known crystal structures of GPCRs
The cannabinoid receptor 2 (CB2) plays an important role in the immune system. Although a
few of GPCRs crystallographic structures have been reported, it is still challenging to obtain …
few of GPCRs crystallographic structures have been reported, it is still challenging to obtain …
The 4-quinolone-3-carboxylic acid motif as a multivalent scaffold in medicinal chemistry
C Mugnaini, S Pasquini, F Corelli - Current medicinal chemistry, 2009 - ingentaconnect.com
Quinolones are among the most common frameworks present in the bioactive molecules
and hence represent an attractive starting point for the design of combinatorial libraries …
and hence represent an attractive starting point for the design of combinatorial libraries …
Cannabinoid receptor subtype 2 (CB2R) in a multitarget approach: perspective of an innovative strategy in cancer and neurodegeneration
The cannabinoid receptor subtype 2 (CB2R) represents an interesting and new therapeutic
target for its involvement in the first steps of neurodegeneration as well as in cancer onset …
target for its involvement in the first steps of neurodegeneration as well as in cancer onset …
Prediction of the binding affinities and selectivity for CB1 and CB2 ligands using homology modeling, molecular docking, molecular dynamics simulations, and MM …
Cannabinoids are a group of chemical compounds that have been used for thousands of
years due to their psychoactive function and systemic physiological effects. There are at …
years due to their psychoactive function and systemic physiological effects. There are at …
Targeting cannabinoid agonists for inflammatory and neuropathic pain
Y Cheng, SA Hitchcock - Expert opinion on investigational drugs, 2007 - Taylor & Francis
The cannabinoid receptors CB1 and CB2 are class A G-protein-coupled receptors. It is well
known that cannabinoid receptor agonists produce relief of pain in a variety of animal …
known that cannabinoid receptor agonists produce relief of pain in a variety of animal …
Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists
JC Ashton, JL Wright, JM McPartland… - Current medicinal …, 2008 - ingentaconnect.com
Cannabinoids in current use such as nabilone activate both CB1 and CB2 receptors.
Selective CB2 activation may provide some of the therapeutic effects of cannabinoids, such …
Selective CB2 activation may provide some of the therapeutic effects of cannabinoids, such …