Transporters and toxicity: insights from the international transporter consortium workshop 4
MJ Hafey, LM Aleksunes, CC Bridges… - Clinical …, 2022 - Wiley Online Library
Over the last decade, significant progress been made in elucidating the role of membrane
transporters in altering drug disposition, with important toxicological consequences due to …
transporters in altering drug disposition, with important toxicological consequences due to …
Contribution of membrane transporters to chemotherapy‐induced cardiotoxicity
Membrane transporters play a key role in determining the pharmacokinetic profile,
therapeutic safety, and efficacy of many chemotherapeutic drugs by regulating cellular influx …
therapeutic safety, and efficacy of many chemotherapeutic drugs by regulating cellular influx …
Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition
Background Inhibition of kinases is the ever-expanding therapeutic approach to various
types of cancer. Typically, assessment of the treatment response is accomplished by …
types of cancer. Typically, assessment of the treatment response is accomplished by …
Deciphering Tumor Response: The Role of Fluoro-18-d-Glucose Uptake in Evaluating Targeted Therapies with Tyrosine Kinase Inhibitors
K Kairemo, M Gouda, HH Chuang… - Journal of Clinical …, 2024 - mdpi.com
Background/Objectives: The inhibitory effects of tyrosine kinase inhibitors (TKIs) on glucose
uptake through their binding to human glucose transporter-1 (GLUT-1) have been well …
uptake through their binding to human glucose transporter-1 (GLUT-1) have been well …
Autophagy and Glycometabolic Reprograming in the Malignant Progression of Lung Cancer: A Review
Y Li, T Liu, X Wang, Y Jia, H Cui - Technology in Cancer …, 2023 - journals.sagepub.com
Lung cancer is one of the leading causes of cancer-related deaths worldwide. However,
there are currently limited treatment options that are widely available to patients with …
there are currently limited treatment options that are widely available to patients with …
Alterations in cellular metabolisms after TKI therapy for Philadelphia chromosome-positive leukemia in children: A review
C Li, L Wen, J Dong, L Li, J Huang, J Yang… - Frontiers in …, 2022 - frontiersin.org
Incidence rates of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive
(Ph+) acute lymphoblastic leukemia (ALL) are lower but more aggressive in children than in …
(Ph+) acute lymphoblastic leukemia (ALL) are lower but more aggressive in children than in …
Role of acetoacetyl-CoA synthetase in glucose uptake by HepG2 cells
S Hasegawa, M Imai, N Takahashi - bioRxiv, 2023 - biorxiv.org
Accelerated glucose metabolism is a common feature of cancer cells and represents a
potential therapeutic target. Recent studies have revealed that lipid metabolism is related to …
potential therapeutic target. Recent studies have revealed that lipid metabolism is related to …
[BUCH][B] Contribution of Membrane Transporters to the Disposition of Organic Cations
ME Uddin - 2022 - search.proquest.com
Membrane transporters play a pivotal role in maintaining cellular integrity via the removal of
toxic metabolites or entry of essential nutrients. Despite regulating cellular influx and efflux …
toxic metabolites or entry of essential nutrients. Despite regulating cellular influx and efflux …