Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …

Cellular senescence is a persistently hypoproliferative state with diverse stressors in a
specific aging microenvironment. Senescent cells have a double‐edged sword effect: they …

Extracellular vesicles (EVs) are important players for intercellular communication. EVs are
secreted by almost all cell types; they can transfer information between nearby or distant …

Intracerebral hemorrhage (ICH), as a type of life-threatening and highly disabled disease,
has limited therapeutic approaches. Here, we show that exosomes derived from young …

The functional competence of the immune system gradually declines with aging, a process
called immunosenescence. The age-related remodelling of the immune system affects both …

Introduction Ischemic stroke-induced inflammation and inflammasome-dependent pyroptotic
neural death cause serious neurological injury. Nano-sized plasma exosomes have …

Extracellular vesicles (EVs) are membrane-enclosed particles secreted by cells and
circulating in body fluids. Initially considered as a tool to dispose of unnecessary material …