Endothelium‐dependent hyperpolarizing factor (EDHF) is a powerful vasodilator influence in
small resistance arteries and thus an important modulator of blood pressure and flow. As the …

This review focuses on the effects of thyroid hormones in vascular and renal systems.
Special emphasis is given to the mechanisms by which thyroid hormones affect the …

Blood flow and blood pressure are determined by an integration of reflex, humoral, and local
vascular control mechanisms. Knowledge of these mechanisms has mushroomed over the …

Hypertension is often characterised by impaired vasodilation involving dysfunction of
multiple vasodilatory mechanisms. ω‐3 polyunsaturated fatty acids (PUFAs) …

Endothelial-dependent relaxation of vascular smooth muscle cells evoked by a number of
agonists, including cholinomimetics and substance P, is often accompanied by an increase …

1. Nitric oxide (NO) relaxes vascular smooth muscle (VSM) by mechanisms which are not
fully understood. One possibility is that NO hyperpolarizes membranes, thereby diminishing …

Our view of the endothelium was transformed around 30 years ago, from one of an inert
barrier to that of a key endocrine organ central to cardiovascular function. This dramatic …

Background—Endothelium-dependent dilatation is mediated by 3 principal vasodilators:
nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived hyperpolarizing factor …

An endothelium‐derived hyperpolarizing factor (EDHF) that is distinct from nitric oxide (NO)
and prostanoids has been widely hypothesized to hyperpolarize and relax vascular smooth …

The endothelium regulates vascular tone through the release of a number of soluble
mediators, including NO, prostaglandin I2, and endothelium-derived hyperpolarizing factor …