Abnormal accumulation of brain iron has been detected in various neurodegenerative
diseases, but the contribution of iron overload to pathology remains unclear. In a group of …

For the last century, there has been great physiological interest in brain iron and its role in
brain function and disease. It is well known that iron accumulates in the brain for people with …

The brain is the seat of body weight homeostasis. However, our inability to control the
increasing prevalence of obesity highlights a need to look beyond canonical feeding …

Abstract T1, T2, and magnetization transfer (MT) measurements were performed in vitro at 3
T and 37° C on a variety of tissues: mouse liver, muscle, and heart; rat spinal cord and …

Quantitative magnetic susceptibility map** (QSM) has recently been introduced to provide
a novel quantitative and local MRI contrast. However, the anatomical contrast represented …

Purpose To evaluate the sensitivity and specificity of quantitative magnetic resonance (MR)
iron map** including R2, R2* and magnetic susceptibility to differentiate patients with …

Purpose To investigate the relationship between transverse relaxation rates R2 and R2*, the
most frequently used surrogate markers for iron in brain tissue, and chemically determined …

After its discovery in 1990, blood oxygenation level-dependent (BOLD) contrast in functional
magnetic resonance imaging (fMRI) has been widely used to map brain activation in …

Previous authors have shown that the transverse relaxivity R2* and frequency shifts that
characterize gradient echo signal decay in magnetic resonance imaging are closely …

This review discusses the major contributors to the subtle magnetic properties of brain tissue
and how they affect MRI contrast. With the increased availability of high‐field scanners, the …