Cerebral small vessel disease (SVD) is common during ageing and can present as stroke,
cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently …

Perivascular spaces include a variety of passageways around arterioles, capillaries and
venules in the brain, along which a range of substances can move. Although perivascular …

Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

The notion of what qualifies as vascular dementia has varied greatly since the first mention
of dementia after apoplexy in ancient literature. Current insight points towards a …

SVD is the leading cause of VCI and is associated with substantial morbidity. Tackling
cardiovascular risk factors is currently the most effective approach to prevent cognitive …

Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Higher order speeded cognitive abilities depend on efficient coordination of activity across
the brain, rendering them vulnerable to age reductions in structural and functional brain …

The original Lothian Birth Cohorts of 1921 (LBC1921) and 1936 (LBC1936) were designed
as follow-up studies to the Scottish Mental Surveys of 1932 (SMS1932) and 1947 …

Introduction Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-
brain barrier (BBB) leakage may be important in SVD-induced brain damage. Methods We …

Objective: In patients with TIA and ischemic stroke, we validated the total small vessel
disease (SVD) score by determining its prognostic value for recurrent stroke. Methods: Two …