DNA helicases, known for their fundamentally important roles in genomic stability, are high
profile players in cancer. Not only are there monogenic helicase disorders with a strong …

RECQ1 (also known as RECQL or RECQL1) belongs to the RecQ family of DNA helicases,
members of which are linked with rare genetic diseases of cancer predisposition in humans …

Despite being the first homolog of the bacterial RecQ helicase to be identified in humans,
the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of …

Purpose The identification of carriers of hereditary breast and ovarian cancer (HBOC) gene
variants through family cancer history alone is suboptimal, and most population-based …

Background Loss-of-function variants in RAD51C are associated with familial ovarian
cancer, but its role in hereditary breast cancer remains unclear. The aim of this study was to …

Molecular testing for hereditary cancers has rapidly advanced over the past two decades.
Next‐generation sequencing has been widely adopted, which has made molecular testing …

Named the “caretakers” of the genome, RecQ helicases function in several pathways to
maintain genomic stability and repair DNA. This highly conserved family of enzymes consist …

Background Knowledge of pathogenic variants in cancer‐predisposing genes is important
when making breast cancer treatment decisions, but genetic testing is not universal and …

Introduction Breast cancer is the most common malignant tumor in women, seriously
threatening health and survival. TP-dependent DNA helicase Q1 (RECQL) is a breast …

Patients harboring germline pathogenic biallelic variants in genes involved in the
recognition and repair of DNA damage are known to have a substantially increased cancer …