Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease
A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …
several types of adipose tissue have been identified, namely white, brown, and beige, that …
The cellular and functional complexity of thermogenic fat
P Cohen, S Kajimura - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …
in the form of heat. These thermogenic fat cells were originally considered to function solely …
Climate change and cardiovascular disease: implications for global health
Climate change is the greatest existential challenge to planetary and human health and is
dictated by a shift in the Earth's weather and air conditions owing to anthropogenic activity …
dictated by a shift in the Earth's weather and air conditions owing to anthropogenic activity …
Cardiovascular and metabolic heterogeneity of obesity: clinical challenges and implications for management
The prevalence of obesity has increased globally over the last 2 decades. Although the body
mass index has been a convenient and simple index of obesity at the population level …
mass index has been a convenient and simple index of obesity at the population level …
A comparative genomics multitool for scientific discovery and conservation
Nature, 2020 - nature.com
Abstract The Zoonomia Project is investigating the genomics of shared and specialized traits
in eutherian mammals. Here we provide genome assemblies for 131 species, of which all …
in eutherian mammals. Here we provide genome assemblies for 131 species, of which all …
Brown and beige fat: physiological roles beyond heat generation
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …
Nitric oxide signalling in cardiovascular health and disease
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
Targeting adipose tissue in the treatment of obesity-associated diabetes
Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …
[HTML][HTML] Mitochondrial uncoupling, ROS generation and cardioprotection
S Cadenas - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2018 - Elsevier
Mitochondrial oxidative phosphorylation is incompletely coupled, since protons translocated
to the intermembrane space by specific respiratory complexes of the electron transport chain …
to the intermembrane space by specific respiratory complexes of the electron transport chain …