The aging process is driven at the cellular level by random molecular damage that slowly
accumulates with age. Although cells possess mechanisms to repair or remove damage …

Endocrine glands communicate with remote target cells via a mixture of continuous and
intermittent signal exchange. Continuous signaling allows slowly varying control, whereas …

It is generally accepted that RANKL is highly expressed in osteoblast precursor cells while
OPG is highly expressed in mature osteoblasts, but to date no functional utility to the BMU …

Objectives To evaluate the clinical PK/PD of PTH (1-34) delivered by a novel transdermal
drug-coated microneedle patch system (ZP-PTH) for the treatment of osteoporosis. Methods …

Bone biology is physiologically complex and intimately linked to calcium homeostasis. The
literature provides a wealth of qualitative and/or quantitative descriptions of cellular …

Abstract The Visual Predictive Check (VPC) is a valuable and supportive instrument for
evaluating model performance. However in its most commonly applied form, the method …

Interferon γ (IFN‐γ) is a cytokine produced locally in the bone microenvironment by cells of
immune origin as well as mesenchymal stem cells. However, its role in normal bone …

Background Multiple myeloma is a hematologic malignancy associated with the
development of a destructive osteolytic bone disease. Results Mathematical models are …

Background Serum tartrate‐resistant acid phosphatase (TRACP) 5b levels were assessed in
predialysis patients with chronic kidney disease (CKD). The aim of the study was to establish …

Although fracture healing is a well-optimized biological process that leads to healing,
approximately 10–20% of fractures result in impaired or delayed healing and these fractures …