Raman spectroscopy has become a versatile tool in protein science and biotechnology.
Recent advances in spectral assignments and vibrational theory, examples of use in …

Peptides and proteins are naturally chiral molecular systems so that sensing their structure
and conformation with chirality-based spectral methods is an obvious and long-used …

The ff94 force field that is commonly associated with the Amber simulation package is one of
the most widely used parameter sets for biomolecular simulation. After a decade of …

The application of Raman spectroscopy to characterize natively unfolded proteins has been
underdeveloped, even though it has significant technical advantages. We propose that a …

The last 15 years have seen a paradigm shift in our understanding of protein biochemistry,
with the realization that an unexpectedly high fraction of the human genome codes for …

The abnormal aggregation of the microtubule-associated protein Tau into paired helical
filaments (PHFs) is one of the hallmarks of Alzheimer disease (AD). Tau in solution behaves …

The ϕ, ψ backbone angle distribution of small homopolymeric model peptides is
investigated by a joint molecular dynamics (MD) simulation and heteronuclear NMR study …

The development of molecular descriptions of intrinsically disordered proteins (IDPs) is
essential for elucidating conformational transitions that characterize common …

Structural characterization of intrinsically disordered proteins (IDPs) is mandatory for
deciphering their potential unique physical and biological properties. A large number of …

An unfolded state ensemble is generated by using a self-avoiding statistical coil model that
is based on backbone conformational frequencies in a coil library, a subset of the Protein …