Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …

There is an epidemic of diabetes in Asia. Type 2 diabetes develops in East Asian patients at
a lower mean body mass index (BMI) compared with those of European descent. At any …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is characterized by
progressive neuropathology and cognitive decline. We performed a cross-tissue analysis of …

Exercise induces signaling networks to improve muscle function and confer health benefits.
To identify divergent and common signaling networks during and after different exercise …

Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and
later in life. Individual studies have shown that epigenetic modifications such as DNA …

Objective: Epigenetic variation may contribute to the development of complex metabolic
diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D …

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci
for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this …

Type 2 diabetes results from a complex interaction between genetic and environmental
factors. Precision medicine for type 2 diabetes using genetic data is expected to predict the …

Type 2 diabetes mellitus (T2DM) is a complex disease in which both genetic and
environmental factors interact in determining impaired β-cell insulin secretion and peripheral …

Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a
large genetic component to be clarified. To explore unidentified loci for T2D, we performed a …