Uric acid is the final product of purine metabolism. Hyperuricemia is defined as a condition
where the level of uric acid exceeds the normal range. The most well-known disease …

Exercise itself is fundamental for good health, and when practiced regularly confers a myriad
of metabolic benefits in a range of tissues. These benefits are mediated by a range of …

Autophagy is a critical regulator of cellular homeostasis, dysregulation of which is
associated with diverse diseases. Here we show therapeutic effects of a novel autophagy …

Epidemiological and clinical studies have long shown that exposure to high levels of heavy
metals are associated with increased risks of neurodegenerative diseases. It is widely …

Background Tumor-associated macrophages (TAMs) play key roles in the development of
many malignant solid tumors including breast cancer. They are educated in the tumor …

Transcription factor EB (TFEB) represents an emerging player in cancer biology. Together
with microphthalmia‐associated transcription factor, transcription factor E3 and transcription …

A reduced risk of obesity and metabolic syndrome has been observed in individuals with a
low intake ratio of linoleic acid/α-linolenic acid (LA/ALA). However, the influence of a low …

Objective: Vascular endothelial cells (ECs) play a critical role in maintaining vascular
homeostasis. Aberrant EC metabolism leads to vascular dysfunction and metabolic …

TFEB is a basic helix-loop-helix transcription factor that confers protection against metabolic
diseases such as atherosclerosis by targeting a network of genes involved in autophagy …

Abstract Birt–Hogg–Dubé syndrome (BHD) is an autosomal dominant disorder
characterized by fibrofolliculomas, pulmonary cysts, pneumothoraces and renal cell …