Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

Research over the last couple of decades has provided novel insights into lactate
neurobiology and the implications of lactate transport-driven neuroenergetics in health and …

Abstract Na+/K+-ATPase is a transmembrane protein that has important roles in the
maintenance of electrochemical gradients across cell membranes by transporting three Na+ …

Parasympathetic neurons in the airways control bronchomotor tone. Increased activity of
cholinergic neurons are mediators of airway hyperresponsiveness (AHR) in asthma …

Rationale: Spinal cord injury (SCI)-induced vascular damage causes ischemia and hypoxia
at the injury site, which, in turn, leads to profound metabolic disruptions. The effects of these …

While embryonic mammalian central nervous system (CNS) axons readily grow and
differentiate, only a minority of fully differentiated mature CNS neurons are able to …

Within an articulately characterized family of ion channels, the voltage-gated sodium
channels, exists a black sheep, SCN7A (Nax). Nax, in contrast to members of its molecular …

Objective To assess the effect of diabetes type on the long‐term rate and extent of epidermal
nerve regeneration. Methods Subjects with well controlled type 1 diabetes mellitus (n= 11) …

Introductions Interstitial cystitis/bladder pain syndrome (IC/BPS) is a poorly understood
chronic disorder characterized by bladder-related pain. Chronic psychological stress plays a …

The early neurodevelopmental contributions of ion pumps remain poorly characterized.
Combining analysis of public human embryo single-cell transcriptomic datasets and an …