The proteasome is an intricate molecular machine, which serves to degrade proteins
following their conjugation to ubiquitin. Substrates dock onto the proteasome at its 19 …

Ubiquitin C-terminal hydrolase L1 (UCH-L1) is an extremely abundant protein in the brain
where, remarkably, it is estimated to make up 1–5% of total neuronal protein. Although it …

UCHL1 is a multifunctional protein expressed at high concentrations in neurons in the brain
and spinal cord. UCHL1 plays important roles in regulating the level of cellular free ubiquitin …

UCHL1/PGP 9.5 (also known as UCHL1 and PGP 9.5) was first detected as a “brain-specific
protein” over 28 years ago. The protein is highly conserved and localized in neurones and …

Ubiquitination/ubiquitylation, one of the most fundamental post-translational modifications,
regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown …

Abstract Three deubiquitinating enzymes—Rpn11, Usp14, and Uch37—are associated with
the proteasome regulatory particle. These enzymes allow proteasomes to remove ubiquitin …

Neurons are highly specialized cells whose connectivity at synapses subserves rapid
information transfer in the brain. Proper information processing, learning, and memory …

Ubiquitin (Ub) is a versatile signaling molecule that plays important roles in a variety of
cellular processes. Cellular Ub pools, which are composed of free Ub and Ub conjugates …

Disarrangement in functions and quality control of mitochondria at synapses are early
events in Alzheimer's disease (AD) pathobiology. We reported that a 20–22 kDa NH2-tau …

The ubiquitin–proteasome system (UPS) is a catalytic machinery that targets numerous
cellular proteins for degradation, thus being essential to control a wide range of basic …