TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate-and Fe2+-
dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has …

Bulk-tissue DNA methylomes represent an average over many different cell types,
hampering our understanding of cell-type-specific contributions to disease development. As …

Pancreatic beta cells play a central role in regulating glucose homeostasis by secreting the
hormone insulin. Failure of beta cells due to reduced function and mass and the resulting …

Type 2 diabetes (T2D) is characterized by insulin resistance along with pancreatic β cell
failure. β cell factors are traditionally thought to control glucose homeostasis by modulating …

Pernicious anemia is a rare condition characterized by vitamin B12 deficiency anemia due
to lack of intrinsic factor, often caused by autoimmune gastritis. Patients with pernicious …

Abstract Purpose of Review Type 1 interferons (IFN-I) are of increasing interest across a
wide range of autoimmune rheumatic diseases. Historically, research into their role in …

In the develo** cortex, postmigratory neurons accumulate in the cortical plate (CP) to
properly differentiate consolidating subtype identities. Microglia, despite their extensive …

Microglia are the resident immune cells of the central nervous system. Microglial progenitors
are generated in the yolk sac during the early embryonic stage. Once microglia enter the …

It has been proposed that unmethylated insulin promoter fragments in plasma derive
exclusively from β cells, reflect their recent demise, and can be used to assess β cell …

Cytosine methylation is a well-explored epigenetic modification mediated by DNA
methyltransferases (DNMTs) which are considered “methylation writers”; cytosine …