2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association
BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …
Mendelian randomization for cardiovascular diseases: principles and applications
Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …
Physiology of sedentary behavior
Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or
reclining posture. Evidence relevant to understanding the physiology of SB can be derived …
reclining posture. Evidence relevant to understanding the physiology of SB can be derived …
[HTML][HTML] Dose–response associations, physical activity intensity and mortality risk: a narrative review
Physical activity is consistently associated with reduced mortality, decreased risk for non-
communicable diseases, and improved mental health in observational studies. Randomized …
communicable diseases, and improved mental health in observational studies. Randomized …
Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome
Metabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic
traits as risk factors. Although the genetics of individual MetS components have been …
traits as risk factors. Although the genetics of individual MetS components have been …
The Rotterdam Study. Design update and major findings between 2020 and 2024
Abstract The Rotterdam Study is a population-based cohort study, started in 1990 in the
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …
Hepatitis B virus infection: An insight into the clinical connection and molecular interaction between hepatitis B virus and host extrahepatic cancer risk
The evidence for chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma
(HCC) occurrence is well established. The hepatocyte epithelium carcinogenesis caused by …
(HCC) occurrence is well established. The hepatocyte epithelium carcinogenesis caused by …
CARE as a wearable derived feature linking circadian amplitude to human cognitive functions
S Cui, Q Lin, Y Gui, Y Zhang, H Lu, H Zhao… - NPJ Digital …, 2023 - nature.com
Circadian rhythms are crucial for regulating physiological and behavioral processes. Pineal
hormone melatonin is often used to measure circadian amplitude but its collection is costly …
hormone melatonin is often used to measure circadian amplitude but its collection is costly …
Physical activity, sedentary behavior, and type 2 diabetes: mendelian randomization analysis
Context The causality and pathways of the associations between physical activity and
inactivity and the risk of type 2 diabetes remain inconclusive. Objective We conducted an …
inactivity and the risk of type 2 diabetes remain inconclusive. Objective We conducted an …
Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study
J Zhu, D Zhou, Y Nie, J Wang, Y Yang… - Journal of cachexia …, 2023 - Wiley Online Library
Background Observational studies have demonstrated a strong bidirectional association
between frailty and depression, but it remains unclear whether this association reflects …
between frailty and depression, but it remains unclear whether this association reflects …