MitoEVs: a new player in multiple disease pathology and treatment

X Zhou, S Liu, Y Lu, M Wan, J Cheng… - Journal of extracellular …, 2023 - Wiley Online Library
Mitochondrial damage plays vital roles in the pathology of many diseases, such as cancers,
neurodegenerative diseases, aging, metabolic diseases and many types of organ injury …

[HTML][HTML] Extracellular vesicles: emerging tools as therapeutic agent carriers

S Liu, X Wu, S Chandra, C Lyon, B Ning, J Fan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …

Biotin–avidin system-based delivery enhances the therapeutic performance of MSC-derived exosomes

D Deng, X Li, JJ Zhang, Y Yin, Y Tian, D Gan, R Wu… - ACS …, 2023 - ACS Publications
Exosomes (EXs) shed by mesenchymal stem cells (MSCs) are potent therapeutic agents
that promote wound healing and regeneration, but when used alone in vivo, their …

Extracellular vesicles and immunity: at the crossroads of cell communication

N Aloi, G Drago, S Ruggieri, F Cibella… - International journal of …, 2024 - mdpi.com
Extracellular vesicles (EVs), comprising exosomes and microvesicles, are small
membranous structures secreted by nearly all cell types. They have emerged as crucial …

The discovery of extracellular vesicles and their emergence as a next-generation therapy

A Rai, B Claridge, J Lozano, DW Greening - Circulation research, 2024 - ahajournals.org
From their humble discovery as cellular debris to cementing their natural capacity to transfer
functional molecules between cells, the long-winded journey of extracellular vesicles (EVs) …

High-throughput capture and in situ protein analysis of extracellular vesicles by chemical probe-based array

X Feng, A Shen, W Zhang, S Jia, A Iliuk, Y Wang… - Nature protocols, 2024 - nature.com
Extracellular vesicles (EVs) are small particles with phospholipid bilayers that carry a
diverse range of cargoes including nucleic acids, proteins and metabolites. EVs have …

A critical systematic review of extracellular vesicle clinical trials

RR Mizenko, M Feaver, BT Bozkurt… - Journal of …, 2024 - Wiley Online Library
This systematic review examines the landscape of extracellular vesicle (EV)‐related clinical
trials to elucidate the field's trends in clinical applications and EV‐related methodologies …

Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

Mitochondrial transfer between cell crosstalk–an emerging role in mitochondrial quality control

Y Liu, T Fu, G Li, B Li, G Luo, N Li, Q Geng - Ageing Research Reviews, 2023 - Elsevier
Intercellular signaling and component conduction are essential for multicellular organisms'
homeostasis, and mitochondrial transcellular transport is a key example of such cellular …

Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling

DM Hermann, L Peruzzotti-Jametti, B Giebel… - Brain, 2024 - academic.oup.com
Extracellular vesicles (EVs) are extremely versatile naturally occurring membrane particles
that convey complex signals between cells. EVs of different cellular sources are capable of …