Mitochondria carry their own genetic information encoding for a subset of protein-coding
genes and translational machinery essential for cellular respiration and metabolism. Despite …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

The most common causes of chronic liver disease are excess alcohol intake, viral hepatitis
and non-alcoholic fatty liver disease, with the clinical spectrum ranging in severity from …

Aging tissues experience a progressive decline in homeostatic and regenerative capacities,
which has been attributed to degenerative changes in tissue-specific stem cells, stem cell …

The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …

Compensatory proliferation triggered by hepatocyte loss is required for liver regeneration
and maintenance but also promotes development of hepatocellular carcinoma (HCC) …

During chronic injury a population of bipotent hepatic progenitor cells (HPCs) become
activated to regenerate both cholangiocytes and hepatocytes. Here we show in human …

Normal tissues accumulate genetic changes with age, but it is unknown if somatic mutations
promote clonal expansion of non-malignant cells in the setting of chronic degenerative …

Pluripotent stem cells have the remarkable self-renewal ability and are capable of
differentiating into multiple diverse cells. There is increasing evidence that the aging process …

Recent evidence has contradicted the prevailing view that homeostasis and regeneration of
the adult liver are mediated by self duplication of lineage-restricted hepatocytes and biliary …