Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders
FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - Elsevier
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …
regulates the size of the blood vessel lumen. We review here the current understanding of …
Mechanisms and physiological implications of cooperative gating of clustered ion channels
Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow
Blood flow into the brain is dynamically regulated to satisfy the changing metabolic
requirements of neurons, but how this is accomplished has remained unclear. Here we …
requirements of neurons, but how this is accomplished has remained unclear. Here we …
[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
Hypoxic pulmonary vasoconstriction
JT Sylvester, LA Shimoda, PI Aaronson… - Physiological …, 2012 - journals.physiology.org
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
B Rode, J Shi, N Endesh, MJ Drinkhill… - Nature …, 2017 - nature.com
Mammalian biology adapts to physical activity but the molecular mechanisms sensing the
activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses …
activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses …
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure
Systemic blood pressure is acutely controlled by total peripheral resistance as determined
by the diameter of small arteries and arterioles, the contractility of which is regulated by …
by the diameter of small arteries and arterioles, the contractility of which is regulated by …
Vitamin D in neurological diseases: a rationale for a pathogenic impact
It is widely known that vitamin D receptors have been found in neurons and glial cells, and
their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical …
their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical …
Signal transduction and regulation in smooth muscle
AP Somlyo, AV Somlyo - Nature, 1994 - nature.com
Smooth muscle cells in the walls of many organs are vital for most bodily functions, and their
abnormalities contribute to a range of diseases. Although based on a sliding-filament …
abnormalities contribute to a range of diseases. Although based on a sliding-filament …