The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Cytosolic double-stranded DNA surveillance by cyclic GMP-AMP synthase (cGAS)–
Stimulator of Interferon Genes (STING) signaling triggers cellular senescence, autophagy …

Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-
long production of blood cells. This process requires major molecular adaptations to allow …

p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …

Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …

Stem cells can reside in a state of reversible growth arrest, or quiescence, for prolonged
periods of time. Although quiescence has long been viewed as a dormant, low-activity state …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Hematopoietic stem cell (HSC) research took hold in the 1950s with the demonstration that
intravenously injected bone marrow cells can rescue irradiated mice from lethality by …