Hepatitis B virus infection

MF Yuen, DS Chen, GM Dusheiko… - Nature reviews Disease …, 2018 - nature.com
Hepatitis B virus (HBV) is a hepatotropic virus that can establish a persistent and chronic
infection in humans through immune anergy. Currently, 3.5% of the global population is …

[HTML][HTML] KASL clinical practice guidelines for management of chronic hepatitis B

Korean Association for the Study of the … - Clinical and …, 2019 - ncbi.nlm.nih.gov
Diseases (AASLD) also presented and continued to revise their clinical practice guidelines,
and the latest updates were in 2015, 2017, and 2018. However, since the medical …

Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial

MF Yuen, J Heo, JW Jang, JH Yoon, YO Kweon… - Nature Medicine, 2021 - nature.com
Chronic infection with hepatitis B virus (HBV) leads to an increased risk of death from
cirrhosis and hepatocellular carcinoma. Functional cure rates are low with current treatment …

Current trends and limitations in dengue antiviral research

JO Obi, H Gutiérrez-Barbosa, JV Chua… - Tropical Medicine and …, 2021 - mdpi.com
Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses

L Eyer, R Nencka, E de Clercq… - Antiviral Chemistry …, 2018 - journals.sagepub.com
Nucleoside analogs represent the largest class of small molecule-based antivirals, which
currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis …

APASL guidance on stop** nucleos (t) ide analogues in chronic hepatitis B patients

JH Kao, WJ Jeng, Q Ning, TH Su, TC Tseng… - Hepatology …, 2021 - Springer
Chronic hepatitis B virus (HBV) infection is currently incurable. Long-term treatment with
potent and safe nucleos (t) ide analogs (NAs) can reduce hepatocellular carcinoma (HCC) …

HBV RNA profiles in patients with chronic hepatitis B under different disease phases and antiviral therapy

LY Mak, G Cloherty, DKH Wong, J Gersch, WK Seto… - Hepatology, 2021 - journals.lww.com
Conclusions HBV RNA showed distinct and corresponding profiles in patients with HBV in
different disease phases. HBV RNA and HBcrAg could be used to monitor residual …

HBV-integration studies in the clinic: role in the natural history of infection

T Pollicino, G Caminiti - Viruses, 2021 - mdpi.com
Hepatitis B virus (HBV) infection is a major global health problem causing acute and chronic
liver disease that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). HBV …

Incidences and determinants of functional cure during entecavir or tenofovir disoproxil fumarate for chronic hepatitis B

YC Hsu, ML Yeh, GLH Wong, CH Chen… - The Journal of …, 2021 - academic.oup.com
Background Long-term incidences and baseline determinants of functional cure (hepatitis B
surface antigen [HBsAg] seroclearance) during entecavir (ETV) or tenofovir disoproxil …

[HTML][HTML] Hepatitis B-related outcomes following direct-acting antiviral therapy in Taiwanese patients with chronic HBV/HCV co-infection

ML Yeh, CF Huang, CI Huang, JA Holmes… - Journal of …, 2020 - Elsevier
Background & Aims The outcome of HBV infection, including the dynamics of HBsAg and
HBV virological reactivation, among patients coinfected with HCV receiving direct-acting …