Clozapine optimization: a delphi consensus guideline from the treatment response and resistance in psychosis working group
Abstract Background and Hypothesis There is limited evidence to guide the approaches to
clozapine treatment. Accordingly, an international initiative was undertaken with the aim of …
clozapine treatment. Accordingly, an international initiative was undertaken with the aim of …
A guideline and checklist for initiating and managing clozapine treatment in patients with treatment-resistant schizophrenia
Abstract Treatment-resistant schizophrenia (TRS) will affect about one in three patients with
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …
Association between clozapine plasma concentrations and treatment response: a systematic review, meta-analysis and individual participant data meta-analysis
Abstract Background and Objectives Although therapeutic drug monitoring of clozapine is
recommended, its optimisation is often adjusted only on the basis of dosage. The aim of this …
recommended, its optimisation is often adjusted only on the basis of dosage. The aim of this …
Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical …
Background The antipsychotic, clozapine, is the only licensed drug against the treatment-
resistant symptoms that affect 20–30% of people with schizophrenia. Clozapine is markedly …
resistant symptoms that affect 20–30% of people with schizophrenia. Clozapine is markedly …
Optimising plasma clozapine levels to improve treatment response: an individual patient data meta-analysis and receiver operating characteristic curve analysis
K Northwood, E Pearson, U Arnautovska… - The British Journal of …, 2023 - cambridge.org
BackgroundAlthough clozapine is the most efficacious medication for treatment-refractory
schizophrenia, not all patients will have an adequate response. Optimising clozapine dose …
schizophrenia, not all patients will have an adequate response. Optimising clozapine dose …
Effect of smoking habits and concomitant valproic acid use on relapse in patients with treatment‐resistant schizophrenia receiving clozapine: A 1‐year retrospective …
Introduction No study has investigated the impact of smoking habits and concomitant
valproic acid (VPA) use on clinical outcomes in maintenance treatment with clozapine. Thus …
valproic acid (VPA) use on clinical outcomes in maintenance treatment with clozapine. Thus …
Third-generation antipsychotics in patients with schizophrenia and non-responsivity or intolerance to clozapine regimen: What is the evidence?
O Vasiliu - Frontiers in psychiatry, 2022 - frontiersin.org
Clozapine is considered «the golden standard» for the management of treatment-resistant
schizophrenia, but many patients do not present adequate responsivity even to this …
schizophrenia, but many patients do not present adequate responsivity even to this …
A systematic review of clozapine for aggression and violence in patients with schizophrenia or schizoaffective disorder
J Faden, L Citrome - Schizophrenia Research, 2024 - Elsevier
Although uncommon, the risk of aggression and violence is greater in people with
schizophrenia than in the general population. Clozapine is the “gold standard” …
schizophrenia than in the general population. Clozapine is the “gold standard” …
Study on the daily dose and serum concentration of clozapine in psychiatric patients and possible influencing factors of serum concentration
T Liu, P Gao, C **e, H Zhang, Z Shi, R Chen - BMC psychiatry, 2023 - Springer
Background Clozapine is the most effective drug for treatment-resistant schizophrenia, and
the dosage and concentration of clozapine in the treatment of mental illness vary greatly in …
the dosage and concentration of clozapine in the treatment of mental illness vary greatly in …
Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits
HÇ Lenk, R Løvsletten Smith… - Clinical and …, 2023 - Wiley Online Library
Clinical response of clozapine is closely associated with serum concentration. Although
tobacco smoking is the key environmental factor underlying interindividual variability in …
tobacco smoking is the key environmental factor underlying interindividual variability in …