Hepatocellular carcinoma pathogenesis: from genes to environment
Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human
population. Despite its significance, there is only an elemental understanding of the …
population. Despite its significance, there is only an elemental understanding of the …
Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword
S Wang, P Chai, R Jia, R Jia - Molecular cancer, 2018 - Springer
Abstract N6-methyladenosine (m 6 A), the most prevalent modification of mammalian RNA,
has received increasing attention. Although m 6 A has been shown to be associated with …
has received increasing attention. Although m 6 A has been shown to be associated with …
RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2
Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional
epigenetic studies have predominantly focused on DNA methylation, histone modifications …
epigenetic studies have predominantly focused on DNA methylation, histone modifications …
Cell-free DNA TAPS provides multimodal information for early cancer detection
Multimodal, genome-wide characterization of epigenetic and genetic information in
circulating cell-free DNA (cfDNA) could enable more sensitive early cancer detection, but it …
circulating cell-free DNA (cfDNA) could enable more sensitive early cancer detection, but it …
[HTML][HTML] Hepatocellular carcinoma: causes, mechanism of progression and biomarkers
Hepatocellular Carcinoma (HCC) is one of the most common malignant tumours in the
world. It is a heterogeneous group of a tumour that vary in risk factor and genetic and …
world. It is a heterogeneous group of a tumour that vary in risk factor and genetic and …
Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival
S Roessler, EL Long, A Budhu, Y Chen, X Zhao, J Ji… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is an aggressive malignancy; its
mechanisms of development and progression are poorly understood. We used an …
mechanisms of development and progression are poorly understood. We used an …
Give lipids a START: the StAR-related lipid transfer (START) domain in mammals
The steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain is a
protein module of∼ 210 residues that binds lipids, including sterols. Fifteen mammalian …
protein module of∼ 210 residues that binds lipids, including sterols. Fifteen mammalian …
Molecular classification and novel targets in hepatocellular carcinoma: recent advancements
Y Hoshida, S Toffanin, A Lachenmayer… - Seminars in liver …, 2010 - thieme-connect.com
Hepatocellular carcinoma (HCC) is one of most lethal cancers worldwide. Strategic
decisions for the advancement of molecular therapies in this neoplasm require a clear …
decisions for the advancement of molecular therapies in this neoplasm require a clear …
GAP control: regulating the regulators of small GTPases
A Bernards, J Settleman - Trends in cell biology, 2004 - cell.com
The small GTPases of the Ras superfamily mediate numerous biological processes through
their ability to cycle between an inactive GDP-bound and an active GTP-bound form. Among …
their ability to cycle between an inactive GDP-bound and an active GTP-bound form. Among …
Rho GTPases: functions and association with cancer
SIJ Ellenbroek, JG Collard - Clinical & experimental metastasis, 2007 - Springer
Rho GTPases are small proteins that act as binary molecular switches in a wide range of
signalling pathways upon stimulation of cell surface receptors. Three different classes of …
signalling pathways upon stimulation of cell surface receptors. Three different classes of …