Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …

Radioresistance is a principal culprit for the failure of radiotherapy in hepatocellular
carcinoma (HCC). Insights on the regulation genes of radioresistance and underlying …

Although the conventional activities of p53 such as cell cycle arrest, senescence, and
apoptosis are well accepted as the major checkpoints in stress responses, accumulating …

Ferroptosis is a type of cell death caused by radical-driven lipid peroxidation, leading to
membrane damage and rupture. Here we show that enzymatically produced sulfane sulfur …

Breast cancer has become one of the top five commonest causes of cancer death. The use
of ferroptosis to induce the generation of reactive oxygen species (ROS) in cancer cells …

Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …

Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …