Curvature in biological systems: its quantification, emergence, and implications across the scales

B Schamberger, R Ziege, K Anselme… - advanced …, 2023 - Wiley Online Library
Surface curvature both emerges from, and influences the behavior of, living objects at length
scales ranging from cell membranes to single cells to tissues and organs. The relevance of …

How physical interactions shape bacterial biofilms

B Maier - Annual Review of Biophysics, 2021 - annualreviews.org
Biofilms are structured communities formed by a single or multiple microbial species. Within
biofilms, bacteria are embedded into extracellular matrix, allowing them to build …

Topological defects promote layer formation in Myxococcus xanthus colonies

K Copenhagen, R Alert, NS Wingreen, JW Shaevitz - Nature Physics, 2021 - nature.com
The soil bacterium Myxococcus xanthus lives in densely packed groups that form dynamic
three-dimensional patterns in response to environmental changes, such as droplet-like …

Morphogenesis and cell ordering in confined bacterial biofilms

Q Zhang, J Li, J Nijjer, H Lu, M Kothari… - Proceedings of the …, 2021 - National Acad Sciences
Biofilms are aggregates of bacterial cells surrounded by an extracellular matrix. Much
progress has been made in studying biofilm growth on solid substrates; however, little is …

Cell shape affects bacterial colony growth under physical confinement

M Sreepadmanabh, M Ganesh, P Sanjenbam… - Nature …, 2024 - nature.com
Evidence from homogeneous liquid or flat-plate cultures indicates that biochemical cues are
the primary modes of bacterial interaction with their microenvironment. However, these …

Self-regulation of phenotypic noise synchronizes emergent organization and active transport in confluent microbial environments

J Dhar, ALP Thai, A Ghoshal, L Giomi, A Sengupta - Nature Physics, 2022 - nature.com
The variation associated with different observable characteristics—phenotypes—at the
cellular scale underpins homeostasis and the fitness of living systems. However, if and how …

Biofilms as self-sha** growing nematics

J Nijjer, C Li, M Kothari, T Henzel, Q Zhang, JSB Tai… - Nature Physics, 2023 - nature.com
Active nematics are the non-equilibrium analogue of passive liquid crystals. They consist of
anisotropic units that consume free energy to drive emergent behaviour. As with liquid …

Microbes in porous environments: from active interactions to emergent feedback

C **, A Sengupta - Biophysical Reviews, 2024 - Springer
Microbes thrive in diverse porous environments—from soil and riverbeds to human lungs
and cancer tissues—spanning multiple scales and conditions. Short-to long-term …

Collective mechano-response dynamically tunes cell-size distributions in growing bacterial colonies

R Wittmann, GHP Nguyen, H Löwen… - Communications …, 2023 - nature.com
Mechanical stresses stemming from environmental factors are a key determinant of cellular
behavior and physiology. Yet, the role of self-induced biomechanical stresses in growing …

Flow-induced symmetry breaking in growing bacterial biofilms

P Pearce, B Song, DJ Skinner, R Mok, R Hartmann… - Physical review …, 2019 - APS
Bacterial biofilms represent a major form of microbial life on Earth and serve as a model
active nematic system, in which activity results from growth of the rod-shaped bacterial cells …