Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Liquid biopsy has been introduced as a new diagnostic concept predicated on the analysis
of circulating tumour cells (CTCs) or circulating tumour-derived factors, in particular, cell-free …

Single-cell technologies have contributed to unravelling tumour heterogeneity, now
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …

Technological innovation and rapid reduction in sequencing costs have enabled the
genomic profiling of hundreds of cancer-associated genes as a component of routine cancer …

The acquisition of ligand‐independent ESR1 mutations during aromatase inhibitor therapy
in metastatic estrogen receptor (ER)‐positive breast cancer is a common mechanism of …

Cancer is a devastating disease that takes the lives of hundreds of thousands of people
every year. Due to disease heterogeneity, standard treatments, such as chemotherapy or …

Abstract The CellSearch® system (CS) enables standardized enrichment and enumeration
of circulating tumor cells (CTCs) that are repeatedly assessable via non-invasive “liquid …

The management of patients with metastatic renal cell carcinoma (RCC) has changed
dramatically over the past few years. Nephrectomy remains an important intervention for …

Background Head and neck squamous cell carcinoma (HNSCC) remain a substantial
burden to global health. Cell-free circulating tumour DNA (ctDNA) is an emerging biomarker …

Liquid biopsies including circulating tumor cells (CTCs) and cell-free DNA (cfDNA) have
enabled minimally invasive characterization of many cancers, but are rarely analyzed …