The prefrontal cortex (PFC) plays a critical role in the generation and regulation of emotion.
However, we lack an integrative framework for understanding how different emotion-related …

This review aims to synthesise a large pre-clinical and clinical literature related to a
hypothesised role of the locus coeruleus norepinephrine system in responses to acute and …

Anxiety is a mental state characterized by an intense sense of tension, worry or
apprehension, relative to something adverse that might happen in the future. Researchers …

The prefrontal cortex (PFC) is a key region implicated in a range of neuropsychiatric
disorders such as depression, schizophrenia and autism. In parallel, the role of the gut …

Highlights•RSA is a valid and reliable biomarker of emotion regulation capacity in
humans.•Low tonic RSA and excessive RSA reactivity to emotion evocation mark PFC …

Rapidly emerging evidence continues to describe an intimate and causal relationship
between sleep and emotional brain function. These findings are mirrored by long-standing …

“A rigorous, in-depth guide to the history, philosophy, and scientific exploration of this
widespread emotional state...[LeDoux] offers a magisterial review of the role of mind and …

This article reviews central nervous system substrates and autonomic correlates of emotion
dysregulation and offers several suggestions for future research. Studies conducted in the …

Metabolic syndrome (MetS), which is characterized by insulin resistance, high blood
glucose, obesity, and dyslipidemia, is known to increase the risk of dementia accompanied …

Increased tonic activity of locus coeruleus noradrenergic (LC-NE) neurons induces anxiety-
like and aversive behavior. While some information is known about the afferent circuitry that …