Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their
rapid and abundant induction by stress. HSP genes are activated at the transcriptional level …

Survivin belongs to the family of apoptosis inhibitors (IAPs), which antagonizes the induction
of cell death. Dysregulated expression of IAPs is frequently observed in cancers, and the …

Acacia hydaspica R. Parker is known for its medicinal uses in multiple ailments. In this study,
we performed bioassay-guided fractionation of cytotoxic compounds from A. hydaspica and …

Combined photothermal and gene therapy provides a promising modality toward cancer
treatment, yet facile integration and controlled codelivery of gene payloads and …

Background Iron binding, naturally occurring protein bovine lactoferrin (bLf) has attracted
attention as a safe anti-cancer agent capable of inducing apoptosis. Naturally, bLf exists …

A novel “collaborative assembly” approach was reported for the synthesis of an siRNA
delivery system via a combination of an electrostatically driven physical assembly and a …

Aptamers are single-stranded structured oligonucleotides (DNA or RNA) that can bind to a
wide range of targets (“apatopes”) with high affinity and specificity. These nucleic acid …

Survivin, a prominent anticancer target, is ubiquitously expressed in a plethora of cancers
and the evolving complexity in functional regulation of survivin is yet to be deciphered …

Breast cancer is the most frequently diagnosed malignancy in American women. While
significant progress has been made in the development of modern diagnostic tools and …

Survivin is an inhibitor of apoptosis protein (IAP) family member preferentially expressed in a
myriad of clinical cancers. The complex functional mechanism and regulatory roles of …