Opportunities and challenges in enhancing the bioavailability and bioactivity of dietary flavonoids: A novel delivery system perspective

D Yuan, Y Guo, F Pu, C Yang, X **ao, H Du, J He, S Lu - Food Chemistry, 2024 - Elsevier
Flavonoids have multiple favorable bioactivities including antioxidant, anti-inflammatory, and
antitumor. Currently, flavonoid-containing dietary supplements are widely tested in clinical …

Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside

A Mishra, R Bandopadhyay, PK Singh, PS Mishra… - Metabolic Brain …, 2021 - Springer
Neuroinflammation is one of the host defensive mechanisms through which the nervous
system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation …

Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress …

MO Yıldız, H Çelik, C Caglayan, FM Kandemir, C Gür… - Neurotoxicology, 2022 - Elsevier
Fluoride is an element with toxic properties and has been proven to have some adverse
effects on many soft tissues, including brain tissue. This study aims to evaluate the protective …

Control of reactive oxygen species for the prevention of Parkinson's disease: the possible application of flavonoids

TY Kim, E Leem, JM Lee, SR Kim - Antioxidants, 2020 - mdpi.com
Oxidative stress reflects an imbalance between the production of reactive oxygen species
(ROS) and antioxidant defense systems, and it can be associated with the pathogenesis and …

[HTML][HTML] Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut− brain axis

Y Kim, J Lim, J Oh - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Alzheimer's disease (AD) is a progressive degenerative neurological condition
characterized by cognitive decline, primarily affecting memory and logical thinking, attributed …

[HTML][HTML] An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches

M Talebi, M Talebi, T Farkhondeh… - Biomedicine & …, 2021 - Elsevier
Neurological diseases are responsible for a large number of morbidities and mortalities in
the world. Flavonoids are phytochemicals that possess various health-promoting impacts …

Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration

M Jazvinšćak Jembrek, N Oršolić, L Mandić, A Sadžak… - Antioxidants, 2021 - mdpi.com
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …

Potential innovation against Alzheimer's disorder: A tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its …

C Karthika, AP Appu, R Akter, MH Rahman… - … Science and Pollution …, 2022 - Springer
Alzheimer's disorder (AD) is very difficult to manage and treat. The complexity of the brain,
the blood–brain barrier influencing a multitude of parameters/biomarkers, as well as …

Neuroprotective potential of chrysin: Mechanistic insights and therapeutic potential for neurological disorders

A Mishra, PS Mishra, R Bandopadhyay, N Khurana… - Molecules, 2021 - mdpi.com
Chrysin, a herbal bioactive molecule, exerts a plethora of pharmacological effects, including
anti-oxidant, anti-inflammatory, neuroprotective, and anti-cancer. A growing body of …

Insights into role of microRNA in Alzheimer's disease: from contemporary research to bedside perspective

M Bandakinda, A Mishra - International Journal of Biological …, 2023 - Elsevier
One of the most prevalent neurodegenerative disorders is Alzheimer's disease (AD). Despite
the pervasiveness of AD being considerable, the rates of both diagnosis and therapy are …