Immunotherapies based on T cells have gained significant success in the treatment of
diverse cancers, however, several limitations also exist, including low response, acquired …

Systemic chemotherapy given at maximum tolerated doses (MTD) has been the mainstay of
cancer treatment for more than half a century. In some chemosensitive diseases such as …

Context: Cyclophosphamide (CTX) is a common anticancer agent used for the treatment of
several malignancies. However, upon treatment, it induces severe toxicity due to its …

A homogeneous sulfated polysaccharide DCS1 was obtained from Dictyosphaeria
cavernosa by alkali extraction and chromatography purification. On the basis of chemical …

In recent years, the immune-potentiating effects of some widely used chemotherapeutic
agents have been increasingly appreciated. This provides a rationale for combining …

Abstract Background Ginsenoside Re (Re) is one of the major components of Panax
ginseng Meyer. Ginsenoside Rk 3 (Rk 3) is a secondary metabolite of Re. The aim of this …

Objective Taking leads from the available research, we aimed to develop a synergy-based
herbal combination of Tinospora cordifolia (TC), Phyllanthus emblica (PE), and Piper nigrum …

Abstract Immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome
is caused by mutations in forkhead box P3 (FOXP3), which lead to the loss of function of …

In clinical trials, metronomic cyclophosphamide (CPA) is increasingly being combined with
vaccines to reduce tumor-induced immune suppression. Previous strategies to modulate the …

Chemotherapeutic agents have profound effects on cancer, stroma and immune cells that–in
most cases–depend upon the dosage and schedule of administration. Preclinical and …