Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases
Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to
manage patients with both periodontitis and RA. This review seeks to provide an update on …
manage patients with both periodontitis and RA. This review seeks to provide an update on …
Targeting TNF/TNFR superfamilies in immune-mediated inflammatory diseases
Dysregulated signaling from TNF and TNFR proteins is implicated in several immune-
mediated inflammatory diseases (IMIDs). This review centers around seven IMIDs …
mediated inflammatory diseases (IMIDs). This review centers around seven IMIDs …
Design and analysis of umbrella trials: Where do we stand?
Background The efficiencies that master protocol designs can bring to modern drug
development have seen their increased utilization in oncology. Growing interest has also …
development have seen their increased utilization in oncology. Growing interest has also …
Towards molecular-pathology informed clinical trials in childhood arthritis to achieve precision medicine in juvenile idiopathic arthritis
In childhood arthritis, collectively known as Juvenile idiopathic arthritis (JIA), the rapid rise of
available licensed biological and targeted small molecule treatments in recent years has led …
available licensed biological and targeted small molecule treatments in recent years has led …
Bayesian modelling strategies for borrowing of information in randomised basket trials
Basket trials are an innovative precision medicine clinical trial design evaluating a single
targeted therapy across multiple diseases that share a common characteristic. To date, most …
targeted therapy across multiple diseases that share a common characteristic. To date, most …
Bayesian borrowing for basket trials with longitudinal outcomes
Basket trials are a novel clinical trial design in which a single intervention is investigated in
multiple patient subgroups, or “baskets.” They offer the opportunity to share information …
multiple patient subgroups, or “baskets.” They offer the opportunity to share information …
Bayesian sample size determination in basket trials borrowing information between subsets
Basket trials are increasingly used for the simultaneous evaluation of a new treatment in
various patient subgroups under one overarching protocol. We propose a Bayesian …
various patient subgroups under one overarching protocol. We propose a Bayesian …
An Access-Focused Patient-Centric Value Assessment Framework for Medication Formulary Decision-Making in Immune-Mediated Inflammatory Diseases
M Yang, M Mittal, AM Fendrick, D Brixner… - Advances in …, 2024 - Springer
The healthcare system in the United States (US) is complex and often fragmented across
national and regional health plans which exhibit substantial variability in benefit design and …
national and regional health plans which exhibit substantial variability in benefit design and …
rBMA: A robust Bayesian Model Averaging Method for phase II basket trials based on informative mixture priors
Oncology drug research in the last few decades has been driven by the development of
targeted agents. In the era of targeted therapies, basket trials are often used to test the …
targeted agents. In the era of targeted therapies, basket trials are often used to test the …
Improving resource utilisation in SLE drug development through innovative trial design
S Garces, E Karis, JT Merrill, AD Askanase… - Lupus Science & …, 2023 - lupus.bmj.com
SLE is a complex autoimmune disease with considerable unmet need. Numerous clinical
trials designed to investigate novel therapies are actively enrolling patients straining limited …
trials designed to investigate novel therapies are actively enrolling patients straining limited …