DNA origami
Biological materials are self-assembled with near-atomic precision in living cells, whereas
synthetic 3D structures generally lack such precision and controllability. Recently, DNA …
synthetic 3D structures generally lack such precision and controllability. Recently, DNA …
Designing spatial and temporal control of vaccine responses
Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …
However, increasing the potency, quality and durability of the vaccine response remains a …
Functionalizing DNA origami to investigate and interact with biological systems
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …
dynamic properties and nanoscale control. These nanostructures enable complex …
Gene-encoding DNA origami for mammalian cell expression
DNA origami may enable more versatile gene delivery applications through its ability to
create custom nanoscale objects with specific targeting, cell-invading, and intracellular …
create custom nanoscale objects with specific targeting, cell-invading, and intracellular …
Nucleic acid tests for clinical translation
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
natural biopolymers composed of nucleotides that store, transmit, and express genetic …
[HTML][HTML] Pursuing excitonic energy transfer with programmable DNA-based optical breadboards
DNA nanotechnology has now enabled the self-assembly of almost any prescribed 3-
dimensional nanoscale structure in large numbers and with high fidelity. These structures …
dimensional nanoscale structure in large numbers and with high fidelity. These structures …
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
PJM Brouwer, M Brinkkemper, P Maisonnasse… - Cell, 2021 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is
continuing to disrupt personal lives, global healthcare systems, and economies. Hence …
continuing to disrupt personal lives, global healthcare systems, and economies. Hence …
Protein-based antigen presentation platforms for nanoparticle vaccines
B Nguyen, NH Tolia - npj Vaccines, 2021 - nature.com
Modern vaccine design has sought a minimalization approach, moving to the isolation of
antigens from pathogens that invoke a strong neutralizing immune response. This approach …
antigens from pathogens that invoke a strong neutralizing immune response. This approach …
Targeted modulation of immune cells and tissues using engineered biomaterials
Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …
[HTML][HTML] Data-driven design and morphological analysis of conical six-fold origami structures
In engineering design, origami structures are frequently characterized by their geometry-
shifting behavior, mechanical properties, lightness, and appealing aesthetic qualities. In …
shifting behavior, mechanical properties, lightness, and appealing aesthetic qualities. In …