[HTML][HTML] Poly (α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives
M Zheng, M Pan, W Zhang, H Lin, S Wu, C Lu, S Tang… - Bioactive Materials, 2021 - Elsevier
Abstract Poly (α-l-lysine)(PLL) is a class of water-soluble, cationic biopolymer composed of α-
l-lysine structural units. The previous decade witnessed tremendous progress in the …
l-lysine structural units. The previous decade witnessed tremendous progress in the …
[HTML][HTML] Polylysine complexes and their biomedical applications
H Zhu, R Liu, Y Shang, L Sun - Engineered Regeneration, 2023 - Elsevier
Abstract Poly-L-lysine (PLL) is a water-soluble biopolymer consist of repeating unit of L-
lysine. It displays intrinsic non-antigenicity, antibacterial property, biocompatibility, and …
lysine. It displays intrinsic non-antigenicity, antibacterial property, biocompatibility, and …
Poly (amino acid) s/polypeptides as potential functional and structural materials
K Numata - Polymer Journal, 2015 - nature.com
Poly (amino acids) and polypeptides have the potential to contribute significantly to a
biomass-based and sustainable society, due to their biomass origin, functionality, and …
biomass-based and sustainable society, due to their biomass origin, functionality, and …
Self-assembled peptide-based system for mitochondrial-targeted gene delivery: functional and structural insights
JA Chuah, A Matsugami, F Hayashi… - …, 2016 - ACS Publications
Human mitochondrial dysfunction can lead to severe and often deadly diseases, for which
there are no known cures. Although the targeted delivery of therapeutic gene to …
there are no known cures. Although the targeted delivery of therapeutic gene to …
Chemoenzymatic synthesis of polypeptides for use as functional and structural materials
K Tsuchiya, K Numata - Macromolecular Bioscience, 2017 - Wiley Online Library
Polypeptides inspired by the natural functional and structural proteins present in living
systems are promising materials for various fields in terms of their versatile functionality and …
systems are promising materials for various fields in terms of their versatile functionality and …
Quantum Chemistry in Drug Design: Density Function Theory (DFT) and Other Quantum Mechanics (QM)-related Approaches
SB de Freitas Rodrigues, RSA de Araújo… - … -Aided Drug Design …, 2023 - benthamdirect.com
Drug design and development are expensive and time-consuming processes, which in
many cases result in failures during the clinical investigation steps. In order to increase the …
many cases result in failures during the clinical investigation steps. In order to increase the …
Polyaminoacid-based nanocarriers: A review of the latest candidates for oral drug delivery
S Robla, MJ Alonso, NS Csaba - Expert Opinion on Drug Delivery, 2020 - Taylor & Francis
Introduction The oral route is one of the most attractive modalities of drug delivery, providing
easy administration and great patient compliance. However, enzymatic degradation and …
easy administration and great patient compliance. However, enzymatic degradation and …
The benzyl ester group of amino acid monomers enhances substrate affinity and broadens the substrate specificity of the enzyme catalyst in chemoenzymatic …
JM Ageitos, K Yazawa, A Tateishi, K Tsuchiya… - …, 2016 - ACS Publications
The chemoenzymatic polymerization of amino acid monomers by proteases involves a two-
step reaction: the formation of a covalent acyl-intermediate complex between the protease …
step reaction: the formation of a covalent acyl-intermediate complex between the protease …
Periodic introduction of aromatic units in polypeptides via chemoenzymatic polymerization to yield specific secondary structures with high thermal stability
K Tsuchiya, N Kurokawa, J Gimenez-Dejoz… - Polymer Journal, 2019 - nature.com
Polypeptides containing periodic aromatic residues in their main chains were synthesized
via papain-catalyzed chemoenzymatic polymerization of tripeptide ester monomers under …
via papain-catalyzed chemoenzymatic polymerization of tripeptide ester monomers under …
Chemoenzymatic Synthesis of Poly-l-lysine via Esterification with Alcohol in One-Pot
K Terada, K Tsuchiya, A Lamprou, K Numata - ACS Polymers Au, 2024 - ACS Publications
Chemoenzymatic polymerization (CEP) using enzymes as catalysts is gaining attention as
an environmentally friendly method for synthesizing polypeptides. This method proceeds …
an environmentally friendly method for synthesizing polypeptides. This method proceeds …