Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …

Recent progress in whole-genome map** and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

Chromosome conformation capture data, particularly from high-throughput approaches such
as Hi-C, are typically very complex to analyse. Existing analysis tools are often single …

Loop-extrusion and phase-separation have been proposed as mechanisms that shape
chromosome spatial organization. It is unclear, however, how they perform relative to each …

The spatial organization of chromosomes has key functional roles, yet how chromosomes
fold remains poorly understood at the single-molecule level. Here, we employ models of …

We review the current applications of artificial intelligence (AI) in functional genomics. The
recent explosion of AI follows the remarkable achievements made possible by “deep …

The genome is the most functional part of a cell, and genomic contents are organized in a
compact three-dimensional (3D) structure. The genome contains millions of nucleotide …

Hi-C, split-pool recognition of interactions by tag extension (SPRITE) and genome
architecture map** (GAM) are powerful technologies utilized to probe chromatin …

The mammalian genome has a complex, functional 3D organization. However, it remains
largely unknown how DNA contacts are orchestrated by chromatin organizers. Here, we …

Genome architecture plays a pivotal role in gene regulation. The use of high-throughput
methods for chromatin profiling and 3-D interaction map** provide rich experimental data …