Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy
Electrical brain stimulation has become an essential treatment option for more than one third
of epilepsy patients who are resistant to pharmacological therapy and are not candidates for …
of epilepsy patients who are resistant to pharmacological therapy and are not candidates for …
Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation
K Hristova, C Martinez-Gonzalez, TC Watson… - Brain, 2021 - academic.oup.com
Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating
focally targeted strategies such as surgical resection or the modulation of the activity of …
focally targeted strategies such as surgical resection or the modulation of the activity of …
Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control
Additional treatment options for temporal lobe epilepsy are needed, and potential
interventions targeting the cerebellum are of interest. Previous animal work has shown …
interventions targeting the cerebellum are of interest. Previous animal work has shown …
[HTML][HTML] The cerebellum's understated role and influences in the epilepsies
Approximately 1 in 26 people will develop epilepsy in their lifetime, but current treatment
options leave as many as half of all epilepsy patients with uncontrolled seizures. In addition …
options leave as many as half of all epilepsy patients with uncontrolled seizures. In addition …
SAFE-OPT: A Bayesian optimization algorithm for learning optimal deep brain stimulation parameters with safety constraints
Objective. To treat neurological and psychiatric diseases with deep brain stimulation (DBS),
a trained clinician must select parameters for each patient by monitoring their symptoms and …
a trained clinician must select parameters for each patient by monitoring their symptoms and …
[PDF][PDF] Are we ready for automated deep brain stimulation programming?
Deep brain stimulation (DBS) requires individualized programming of stimulation
parameters, a time-consuming process performed manually by clinicians with specialized …
parameters, a time-consuming process performed manually by clinicians with specialized …
Biofluid-Permeable and Erosion-Resistant Wireless Neural-Electronic Interfaces for Neurohomeostasis Modulation
Z Wei, F **, T Li, Y He, L Qian, J Ma, T Yuan, X Yu… - ACS …, 2025 - ACS Publications
Neural-electronic interfaces through delivering electroceuticals to lesions and modulating
pathological endogenous electrical environments offer exciting opportunities to treat drug …
pathological endogenous electrical environments offer exciting opportunities to treat drug …
Irregular optogenetic stimulation waveforms can induce naturalistic patterns of hippocampal spectral activity
Objective: Therapeutic brain stimulation is conventionally delivered using constant-
frequency stimulation pulses. Several recent clinical studies have explored how …
frequency stimulation pulses. Several recent clinical studies have explored how …
Efficacy of different strategies of responsive neurostimulation on seizure control and their association with acute neurophysiological effects in rats
F Zhang, Y Yang, Y **n, Y Sun, C Wang, J Zhu… - Epilepsy & Behavior, 2023 - Elsevier
Responsive neurostimulation (RNS) has shown promising but limited efficacy in the
treatment of drug-resistant epilepsy. The clinical utility of RNS is hindered by the incomplete …
treatment of drug-resistant epilepsy. The clinical utility of RNS is hindered by the incomplete …
A framework for designing data-driven optimization systems for neural modulation
Objective. Neural modulation is a fundamental tool for understanding and treating
neurological and psychiatric diseases. However, due to the high-dimensional space, subject …
neurological and psychiatric diseases. However, due to the high-dimensional space, subject …