Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Metabolic engineering of Escherichia coli for natural product biosynthesis

D Yang, SY Park, YS Park, H Eun, SY Lee - Trends in Biotechnology, 2020 - cell.com
Natural products are widely employed in our daily lives as food additives, pharmaceuticals,
nutraceuticals, and cosmetic ingredients, among others. However, their supply has often …

Systems metabolic engineering of microorganisms for food and cosmetics production

KR Choi, SY Lee - Nature Reviews Bioengineering, 2023 - nature.com
The demand for sustainable and environmentally friendly sources of foods and cosmetics is
increasing owing to concerns about the rapid growth of the global population and climate …

Fourth generation biofuel from genetically modified algal biomass: Challenges and future directions

H Shokravi, Z Shokravi, M Heidarrezaei, HC Ong… - Chemosphere, 2021 - Elsevier
Genetic engineering applications in the field of biofuel are rapidly expanding due to their
potential to boost biomass productivity while lowering its cost and enhancing its quality …

Engineering extracellular electron transfer pathways of electroactive microorganisms by synthetic biology for energy and chemicals production

J Zhang, F Li, D Liu, Q Liu, H Song - Chemical Society Reviews, 2024 - pubs.rsc.org
The excessive consumption of fossil fuels causes massive emission of CO2, leading to
climate deterioration and environmental pollution. The development of substitutes and …

Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis

B Hu, H Yu, J Zhou, J Li, J Chen, G Du… - Advanced …, 2023 - Wiley Online Library
By exploiting versatile P450 enzymes, whole‐cell biocatalysis can be performed to
synthesize valuable compounds in Escherichia coli. However, the insufficient supply of …

Production of Rainbow Colorants by Metabolically Engineered Escherichia coli

D Yang, SY Park, SY Lee - Advanced Science, 2021 - Wiley Online Library
There has been much interest in producing natural colorants to replace synthetic colorants
of health concerns. Escherichia coli has been employed to produce natural colorants …

Targeted and high-throughput gene knockdown in diverse bacteria using synthetic sRNAs

JS Cho, D Yang, CPS Prabowo, MR Ghiffary… - Nature …, 2023 - nature.com
Synthetic sRNAs allow knockdown of target genes at translational level, but have been
restricted to a limited number of bacteria. Here, we report the development of a broad-host …

[HTML][HTML] Rebalancing microbial carbon distribution for L-threonine maximization using a thermal switch system

Y Fang, J Wang, W Ma, J Yang, H Zhang, L Zhao… - Metabolic …, 2020 - Elsevier
In metabolic engineering, unbalanced microbial carbon distribution has long blocked the
further improvement in yield and productivity of high-volume natural metabolites. Current …

Advances and prospects in metabolic engineering of Escherichia coli for L-tryptophan production

S Liu, JZ Xu, WG Zhang - World Journal of Microbiology and …, 2022 - Springer
As an important raw material for pharmaceutical, food and feed industry, highly efficient
production of L-tryptophan by Escherichia coli has attracted a considerable attention …