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HIV infection
The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …
HIV and antiretroviral therapy-related fat alterations
Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …
Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2022 recommendations of the International Antiviral Society–USA panel
Importance Recent advances in treatment and prevention of HIV warrant updated
recommendations to guide optimal practice. Objective Based on a critical evaluation of new …
recommendations to guide optimal practice. Objective Based on a critical evaluation of new …
Cabotegravir for HIV prevention in cisgender men and transgender women
Background Safe and effective long-acting injectable agents for preexposure prophylaxis
(PrEP) for human immunodeficiency virus (HIV) infection are needed to increase the options …
(PrEP) for human immunodeficiency virus (HIV) infection are needed to increase the options …
Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a …
Background Tenofovir alafenamide shows high antiviral efficacy and improved renal and
bone safety compared with tenofovir disoproxil fumarate when used for HIV treatment. Here …
bone safety compared with tenofovir disoproxil fumarate when used for HIV treatment. Here …
Dolutegravir with emtricitabine and tenofovir alafenamide or tenofovir disoproxil fumarate versus efavirenz, emtricitabine, and tenofovir disoproxil fumarate for initial …
Background ADVANCE compared the efficacy and safety of two antiretroviral first-line
combinations (dolutegravir combined with emtricitabine and either tenofovir disoproxil …
combinations (dolutegravir combined with emtricitabine and either tenofovir disoproxil …
Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2020 recommendations of the International Antiviral Society–USA Panel
Importance Data on the use of antiretroviral drugs, including new drugs and formulations, for
the treatment and prevention of HIV infection continue to guide optimal practices. Objective …
the treatment and prevention of HIV infection continue to guide optimal practices. Objective …
Efficacy and safety of switching to the 2-drug regimen dolutegravir/lamivudine versus continuing a 3-or 4-drug regimen for maintaining virologic suppression in adults …
Background In TANGO, switching to dolutegravir/lamivudine (DTG/3TC) demonstrated long-
term noninferior efficacy vs continuing tenofovir alafenamide–based regimens in treatment …
term noninferior efficacy vs continuing tenofovir alafenamide–based regimens in treatment …
Weight gain among treatment‐naïve persons with HIV starting integrase inhibitors compared to non‐nucleoside reverse transcriptase inhibitors or protease inhibitors …
Introduction Weight gain following antiretroviral therapy (ART) initiation is common,
potentially predisposing some persons with HIV (PWH) to cardio‐metabolic disease. We …
potentially predisposing some persons with HIV (PWH) to cardio‐metabolic disease. We …
Long-acting cabotegravir plus rilpivirine for treatment in adults with HIV-1 infection: 96-week results of the randomised, open-label, phase 3 FLAIR study
Background There is a need for more convenient, less frequent treatment to help address
challenges associated with daily oral HIV treatment in people living with HIV, including …
challenges associated with daily oral HIV treatment in people living with HIV, including …