Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Direct neuronal reprogramming is a promising approach to regenerate neurons from local
glial cells. However, mechanisms of epigenome remodeling and co-factors facilitating this …

We have recently demonstrated that reactive glial cells can be directly reprogrammed into
functional neurons by a single neural transcription factor, NeuroD1. Here we report that a …

Multipotent neural progenitor cells (NPCs) undergo self-renewal while producing neurons,
astrocytes, and oligodendrocytes. These processes are controlled by multiple basic helix …

Developmental programs that generate the astonishing neuronal diversity of the nervous
system are not completely understood and thus present a major challenge for clinical …

Techniques for reprogramming somatic cells create new opportunities for drug screening,
disease modeling, artificial organ development, and cell therapy. The development of …

The transcriptome of every cell is orchestrated by the complex network of interaction
between transcription factors (TFs) and their binding sites on DNA. Disruption of this network …

Neurogenins are proneural transcription factors required to specify neuronal identity. Their
overexpression in human pluripotent stem cells rapidly produces cortical-like neurons with …

Pro-neural transcription factors and small molecules can induce the reprogramming of
fibroblasts into functional neurons; however, the immediate-early molecular events that …