Drug resistance in epilepsy

E Perucca, P Perucca, HS White, EC Wirrell - The Lancet Neurology, 2023 - thelancet.com
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its
prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other …

Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

Modulating brain activity with invasive brain–computer interface: a narrative review

ZP Zhao, C Nie, CT Jiang, SH Cao, KX Tian, S Yu… - Brain sciences, 2023 - mdpi.com
Brain-computer interface (BCI) can be used as a real-time bidirectional information gateway
between the brain and machines. In particular, rapid progress in invasive BCI, propelled by …

[HTML][HTML] Epileptic-network-based prediction and control of seizures in humans

K Lehnertz, T Bröhl, R von Wrede - Neurobiology of disease, 2023 - Elsevier
Epilepsy is now conceptualized as a network disease. The epileptic brain network
comprises structurally and functionally connected cortical and subcortical brain regions …

Neurostimulation in generalized epilepsy: a systematic review and meta‐analysis

Z Haneef, HC Skrehot - Epilepsia, 2023 - Wiley Online Library
Objective There are three neurostimulation devices available to treat generalized epilepsy:
vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive …

Neuro-stimulation in focal epilepsy: A systematic review and meta-analysis

HC Skrehot, DJ Englot, Z Haneef - Epilepsy & Behavior, 2023 - Elsevier
Objectives Different neurostimulation modalities are available to treat drug-resistant focal
epilepsy when surgery is not an option including vagus nerve stimulation (VNS), responsive …

Use of recommended neurodiagnostic evaluation among patients with drug-resistant epilepsy

M Spotnitz, CD Ekanayake, A Ostropolets… - JAMA …, 2024 - jamanetwork.com
Importance Interdisciplinary practice parameters recommend that patients with drug-
resistant epilepsy (DRE) undergo comprehensive neurodiagnostic evaluation, including …

Advances in therapy for refractory epilepsy

L Jehi - Annual Review of Medicine, 2024 - annualreviews.org
Drug-resistant epilepsy (DRE) is defined as failure to achieve sustained seizure control with
adequate trials of two appropriate antiseizure medications (ASMs). DRE affects one-third of …

Idiopathic generalized epilepsy: misunderstandings, challenges, and opportunities

O Devinsky, C Elder, S Sivathamboo, IE Scheffer… - Neurology, 2024 - neurology.org
The idiopathic generalized epilepsies (IGE) make up a fifth of all epilepsies, but< 1% of
epilepsy research. This skew reflects misperceptions: diagnosis is straightforward …

Pediatric neuromodulation for drug‐resistant epilepsy: Survey of current practices, techniques, and outcomes across US epilepsy centers

CN Joshi, C Karakas, K Eschbach, D Samanta… - Epilepsia …, 2024 - Wiley Online Library
Abstract Neuromodulation via Responsive Neurostimulation (RNS) or Deep Brain
Stimulation (DBS) is an emerging treatment strategy for pediatric drug‐resistant epilepsy …