Hexokinases
JE Wilson - Reviews of Physiology, Biochemistry and …, 2006 - Springer
The transfer of a phosphoryl moiety from ATP to an acceptor group is an essential step,
frequently the initial step, in the metabolism of many molecules. Hence, kinases represent a …
frequently the initial step, in the metabolism of many molecules. Hence, kinases represent a …
What determines the intracellular ATP concentration
FI Ataullakhanov, VM Vitvitsky - Bioscience reports, 2002 - portlandpress.com
Analysis is made of the mechanisms that control the intracellular ATP level. The balance
between energy production and expenditure determines the energy charge of the cell and …
between energy production and expenditure determines the energy charge of the cell and …
The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action
PR Kuser, S Krauchenco, OAC Antunes… - Journal of Biological …, 2000 - ASBMB
Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a
phosphoryl group from ATP to glucose to form glucose 6-phosphate and ADP. Two yeast …
phosphoryl group from ATP to glucose to form glucose 6-phosphate and ADP. Two yeast …
Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia
MV Martinov, AG Plotnikov, VM Vitvitsky… - … et Biophysica Acta (BBA …, 2000 - Elsevier
The critical minimum values of Na, K-ATPase and glycolytic enzyme activities at which the
erythrocyte viability is lost were calculated using the mathematical model of the erythrocyte …
erythrocyte viability is lost were calculated using the mathematical model of the erythrocyte …
Effect of pH on the stability and structure of yeast hexokinase A: acidic amino acid residues in the cleft region are critical for the opening and the closing of the structure
pH and salts have a marked effect on the stability, structure, and function of many globular
proteins due to their ability to influence the electrostatic interactions. In this work, calorimetry …
proteins due to their ability to influence the electrostatic interactions. In this work, calorimetry …
Erythrocytes as bioreactors to decrease excess ammonium concentration in blood
ES Protasov, DV Borsakova, YG Alexandrovich… - Scientific Reports, 2019 - nature.com
Increased blood ammonium concentrations cause neurological complications. Existing
drugs are not always sufficiently effective. Alternatively, erythrocytes-bioreactors (EBRs) …
drugs are not always sufficiently effective. Alternatively, erythrocytes-bioreactors (EBRs) …
Hexokinase mutations that produce nonspherocytic hemolytic anemia
Among glycolytic enzyme defects, hexokinase (ATP: D-hexose 6-phosphotransferase, EC
2.7. 1.1; HK) deficiency is a very rare disease where the predominant clinical effect is …
2.7. 1.1; HK) deficiency is a very rare disease where the predominant clinical effect is …
Improved metabolic properties of hexokinase-overloaded human erythrocytes
Human erythrocytes were loaded with homogeneous hexokinase purified from human
placenta (an enzyme species apparently identical to the erythrocyte enzyme), using a …
placenta (an enzyme species apparently identical to the erythrocyte enzyme), using a …
[HTML][HTML] A Novel Pathogenic Sense Variant in Exon 7 of the HK1 Gene in a Patient with Hexokinase Deficiency and Gilbert Syndrome
M Bartnik, W Pawlik, B Burzyńska, K Wasilewski… - Genes, 2024 - mdpi.com
Background: Hexokinase (HK) deficiency is a rare autosomal recessively inherited disease
manifested by chronic nonspherocytic hemolytic anemia. Most patients present with a mild to …
manifested by chronic nonspherocytic hemolytic anemia. Most patients present with a mild to …
Molecular characterization of six new cases of red blood cell hexokinase deficiency yields four novel mutations in HK1
P Koralkova, R Mojzikova, B van Oirschot… - Blood Cells, Molecules …, 2016 - Elsevier
Hexokinase (HK) is a key enzyme of glycolysis, the only metabolic pathway able to provide
the red blood cell with ATP. HK deficiency is a very rare hereditary disorder with severe …
the red blood cell with ATP. HK deficiency is a very rare hereditary disorder with severe …