Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …

Abstract Purpose of Review Over the past decades, osteocytes have emerged as mechano-
sensors of bone and master regulators of bone homeostasis. This article summarizes latest …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Osteoclasts and osteoblasts play a major role in bone tissue homeostasis. The homeostasis
and integrity of bone tissue are maintained by ensuring a balance between osteoclastic and …

Skeletal homeostasis requires the continued replenishment of the bone forming osteoblast
from a mesenchymal stem cell (MSC) population, a process that has been shown to be …

Bones are constantly exposed to mechanical forces from both muscles and Earth's gravity to
maintain bone homeostasis by stimulating bone formation. Mechanotransduction transforms …

Bone is a mechano-responsive tissue that adapts to changes in its mechanical environment.
Increases in strain lead to increased bone mass acquisition, whereas decreases in strain …

Bone marrow mesenchymal stem cells (BMSCs) refer to a heterogeneous population of cells
with the capacity for self-renewal. BMSCs have multi-directional differentiation potential and …

Cells are known to perceive their microenvironment through extracellular and intracellular
mechanical signals. Upon sensing mechanical stimuli, cells can initiate various downstream …